Substituted thiomorpholine derivatives

A method of treating epilepsy comprising administering an anti-convulsive and a compound of formula I:

• wherein
• q is 0 or 1;
• W is O;
• X is CO;
• Z is O;
• R1 is selected from the group consisting of halogen, cyano, C1-6-alk(en/yn)yl, C3-8-cycloalk(en)yl, C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl, halo-C1-6-alk(en/yn)yl, halo-C3-8-cycloalk(en)yl, halo-C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl, C1-6-alk(en/yn)yloxy, C3-8-cycloalk(en)yloxy and C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yloxy;
• R2 is selected from the group consisting of halogen, cyano, C1-6-alk(en/yn)yl, C3-8-cycloalk(en)yl, C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl, halo-C1-6-alk(en/yn)yl, halo-C3-8-cycloalk(en)yl, halo-C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl, C1-6-alk(en/yn)yloxy, C3-8-cycloalk(en)yloxy, C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yloxy, optionally substituted phenyl and optionally substituted pyridyl;
• wherein phenyl and pyridyl are optionally substituted with one or more substituents independently being halogen, C1-6-alk(en/yn)yl, C3-8-cycloalk(en)yl or C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl;
• R3 is selected from the group consisting of C1-10-alk(en/yn)yl, C3-8-cycloalk(en)yl, C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl, Ar—C1-6-alk(en/yn)yl, Ar—C3-8-cycloalk(en)yl, Ar—C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl and Ar;
• and
• each of R4, R5, R6 and R7 is independently selected from the group consisting of hydrogen and Ar;
• wherein Ar is selected from the group consisting of phenyl, naphthyl, pyridine, optionally substituted thiophene, furan, thiazole, quinoline, indole, 2,3-dihydro-benzofuran, pyrimidine, pyrrole and oxazole;
• in which the Ar is optionally substituted with one or more substituents independently being hydroxy, halogen, C1-6-alk(en/yn)yl, C3-8-cycloalk(en)yl, C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl, halo-C1-6-alk(en/yn)yl, C1-6-alk(en/yn)yloxy, C3-8-alk(en/yn)yloxy, acyl, nitro or cyano, —CO—NH—C1-6-alk(en/yn)yl, —CO—N(C1-6-alk(en/yn)yl2, —NH2, —NH—C1-6-alk(en/yn)yl, —N(C1-6-alk(en/yn)yl)2, —S—C1-6-alk(en/yn)yl, —SO2—C1-6-alk(en/yn)yl, —SO2N(C1-6-alk(en/yn)yl)2 and —SO2NH—C1-6-alk(en/yn)yl;
• or two adjacent substituents may together with the aromatic group to which they are attached form a 4-8 membered ring, which optionally contains one, two or three heteroatoms;
• when Ar is substituted with CO—NH—C1-6-alk(en/yn)yl or CO—N(C1-6-alk(en/yn)yl)2, then the carbon atom of the CO group is attached to Ar;
• when Ar is substituted with NH2, NH—C1-6-alk(en/yn)yl or N(C1-6-alk(en/yn)yl)2, then the nitrogen atom is attached to Ar;
• when Ar is substituted with —S—C1-6-alk(en/yn)yl, —SO2—C1-6-alk(en/yn)yl), —SO2N(C1-6-alk(en/yn)yl)2 or —SO2NH—C1-6-alk(en/yn)yl then the sulphur atom is attached to Ar;
• or a salt thereof.