Amido-thiophene compounds and their use

A compound selected from compounds of the following formula, and pharmaceutically acceptable salts thereof:

• wherein:
• —R2 is independently —R2B;
• —R3 is independently —H;
• —R5 is independently —H;
• and
• -Z is independently -J1 or J2;
• wherein:
• —R2B is independently pyrazolyl, and is optionally substituted with one or more substituents independently selected from:
• —RX1, —F, —Cl, —Br, —OH, ORX1, —CN, —NH2, —NHRX1, or —NRX12;
• wherein each —RX1 is independently saturated aliphatic C1-4alkyl;
• wherein:
• -J1 is independently a monocyclic non-aromatic heterocyclyl group having from 4 to 8 ring atoms, wherein exactly 1 of said ring atoms is a ring heteroatom, and is N, or exactly 2 of said ring atoms are ring heteroatoms, and are both N, or exactly 2 of said ring atoms are ring heteroatoms, and are N and O, or exactly 2 of said ring atoms are ring heteroatoms, and are N and S, and wherein said non-aromatic heterocyclyl group is optionally substituted;
• and
• -J2 is independently a fused bicyclic non-aromatic heterocyclyl group having from 7 to 12 ring atoms, wherein exactly 1 of said ring atoms is a ring heteroatom, and is N, or exactly 2 of said ring atoms are ring heteroatoms, and are both N, or exactly 2 of said ring atoms are ring heteroatoms, and are N and O, or exactly 2 of said ring atoms are ring heteroatoms, and are N and S, or exactly 3 of said ring atoms are ring heteroatoms, one of which is N, and each of the other two is independently N, O, or S, and wherein said fused bicyclic non-aromatic heterocyclyl group is optionally substituted;
• wherein:
• each of -J1 and J2 is optionally substituted with one or more substituents independently selected from:
• substituents on carbon, independently selected from:
• —RQ, —RR, RLRR, F, —Cl, —Br, —OH, —RL—OH, —ORP, —RL—ORP, —NH2, —NHRP, —NRP2, and —CN;
• and
• substituents on nitrogen, if present, independently selected from:
• —RQ, —RR, —RL—RR, and —S(═O)2RP,
• wherein:
• each —RP is independently —Re, —RR, or —RL—RR;
• each —RQ is independently saturated aliphatic C1-4alkyl, and is optionally substituted with one or more fluorine atoms;
• each —RR is independently phenyl, furanyl, thienyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, tetrazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyridyl, pyrimidinyl, or pyridazinyl, and is optionally substituted with one or more substituents independently selected from:
• —F, —Cl, —Br,
• —RK1, —CF3,
• —OH, —OCF3,
• —NH2, —NHRK1, —NRK12, and
• —CN;
• wherein each —RK1 is independently saturated aliphatic C1-4alkyl;
• and
• each —RL— is independently saturated aliphatic C1-4alkylene.