US 8,299,056 B2Granted

Aminotriazolopyridines, compositions thereof, and methods of treatment therewith

AssigneeSignal Pharmaceuticals, LLC

InventorsSogole Bahmanyar, R.J. Bates, Kate Blease, Andrew Calabrese, Thomas Daniel, Mercedes Delgado, Jan Elsner, Paul Erdman, Bruce Fahr, Gregory Ferguson, Branden Lee, Lisa Nadolny, Garrick Packard, Patrick Papa, Veronique Plantevin-Krenitsky, Jennifer Riggs, Patricia Rohane, Sabita Sankar, John Sapienza, Yoshitaka Satoh, Victor Sloan, Randall Stevens, Lida Tehrani, Jayashree Tikhe, Eduardo Torres, Andrew Wallace, Brandon Wade Whitefield, Jingjing Zhao

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Abstract

Provided herein are Heteroaryl Compounds of formula (I): wherein R1 and R2 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing inflammatory conditions or cancer, and conditions treatable or preventable by inhibition of a kinase or a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a subject in need thereof.

Claims31

Dependent claims

A compound of formula (I):

or pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein:
R1 is a substituted or unsubstituted aryl, or a substituted or unsubstituted heterocyclyl;
R2 is a substituted C1-8 alkyl, an unsubstituted non-aromatic cycloalkyl, an unsubstituted non-aromatic heterocyclylalkyl, an unsubstituted aralkyl, —NR3R4, —OR3, —C(═O)R5, —C(═O)NR3R4, —NHC(═O)R3, —(CH2)0-2CR6(OR3)R4, or an unsubstituted heterocyclyl selected from azetidinyl, pyrrolidyl, morpholinyl, 1,2,3,6-tetrahydropyridyl, isoxazolyl, imidazolyl, indazolyl, benzimidazolyl, benzisoxazolyl, benzo[d]oxazolyl, isoindolin-1-onyl, isoquinolinyl, or quinolyl;
R3 and R4 are at each occurrence independently —H, a substituted or unsubstituted C1-8 alkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted heteroaryl, a substituted or unsubstituted cycloalkyl, a substituted or unsubstituted heterocyclyl, a substituted or unsubstituted aralkyl, or a substituted or unsubstituted heterocyclylalkyl;
R5 is substituted or unsubstituted C1-8 alkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted heteroaryl, a substituted or unsubstituted cycloalkyl, a substituted or unsubstituted heterocyclyl, a substituted or unsubstituted aralkyl, or a substituted or unsubstituted heterocyclylalkyl;
and
R6 is —H, or a substituted or unsubstituted C1-8 alkyl, or together with R4 and the atoms to which they are attached form a substituted or unsubstituted heterocyclyl;
provided the compound is not N5-cyclopentyl-N2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine.

5 more elements

A compound, wherein the compound is

1-methyl-N3-(tetrahydro-2H-pyran-4-yl)-N6-(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-1H-indazole-3,6-diamine;
N3-(tetrahydro-2H-pyran-4-yl)-N6-(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-1H-indazole-3,6-diamine;
1-methyl-N3-(piperidin-4-yl)-N6-(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-1H-indazole-3,6-diamine;
cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one;
cis-6-(5-(4-hydroxy-4-methylcyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1,3,3-trimethylindolin-2-one;
N-(3-(methoxymethyl)-1H-indazol-6-yl)-5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
cis-4-(2-(5-methyl-6-morpholinopyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
N-(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-1H-pyrazolo[4,3-b]pyridin-6-amine;
cis-4-(2-(1H-pyrazolo[4,3-b]pyridin-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
N2-(3,4-dimethyl-1H-indazol-6-yl)-N5-(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3,4-trimethylindolin-2-one;
trans-6-(5-(4-hydroxy-4-methylcyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1,3,3-trimethylindolin-2-one;
N2-(1H-pyrazolo[4,3-b]pyridin-6-yl)-N5-(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
cis-4-(2-(imidazo[1,2-a]pyridin-7-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
3,3-dimethyl-6-(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)isoindolin-1-one;
6-(5-(4-hydroxypiperidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one;
(R)—N2-(3-methyl-1H-indazol-5-yl)-N5-(tetrahydrofuran-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
N-(3-methyl-1H-indazol-5-yl)-5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
N2-(3-methyl-1H-indazol-5-yl)-N5-(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
1-methyl-6-(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one;
1-methyl-6-(5-(tetrahydro-2H-pyran-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one;
cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylisoindolin-1-one;
(S)-3,3-dimethyl-6-(5-(methyl(tetrahydrofuran-3-yl)amino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one;
(R)-3,3-dimethyl-6-(5-(methyl(tetrahydrofuran-3-yl)amino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one;
(R)-1,3,3-trimethyl-6-(5-(tetrahydrofuran-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one;
4-((2-(4-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)pyridine-2-ol;
3,3,4-trimethyl-6-(5-(tetrahydro-2H-pyran-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one;
3,3,4-trimethyl-6-(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one;
trans-4-(2-(3-methyl-1H-indazol-5-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
3,3-dimethyl-6-(5-(tetrahydro-2H-pyran-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)isoindolin-1-one;
N5-(tetrahydro-2H-pyran-4-yl)-N2-(3-(trifluoromethyl)-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
4-((2-(2-(methoxymethyl)-1H-benzo[d]imidazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)pyridine-2-ol;
(R)-3,3-dimethyl-6-(5-(piperidin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one;
N-(2-(methoxymethyl)-1H-benzo[d]imidazol-6-yl)-5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
(S)-3,3-dimethyl-6-(5-(tetrahydrofuran-3-yloxy)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one;
(R)-3,3-dimethyl-6-(5-(tetrahydrofuran-3-yloxy)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one;
cis-5-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-2-methylisoindolin-1-one;
1,3,3-trimethyl-6-(5-((3-oxopiperazin-1-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one;
trans-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylisoindolin-1-one;
3,3-dimethyl-6-(5-(piperidin-4-ylmethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one;
cis-4-(2-(1-methyl-1H-pyrazolo[3,4-b]pyridin-5-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
cis-6-(5-((4-hydroxy-4-methylcyclohexyl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one;
trans-6-(5-((4-hydroxy-4-methylcyclohexyl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one;
N2-(2-(methoxymethyl)-1H-benzo[d]imidazol-6-yl)-N5-(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
1,3,3-trimethyl-6-(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one;
2-methyl-5-(5-(tetrahydro-2H-pyran-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)isoindolin-1-one;
2-methyl-5-(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)isoindolin-1-one;
trans-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1,3,3-trimethylindolin-2-one;
N-(1,4-dimethyl-1H-indazol-6-yl)-5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
N2-(1,4-dimethyl-1H-indazol-6-yl)-N5-(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
cis-4-(2-(4-fluoro-1,3-dimethyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
(R)-3,3-dimethyl-6-(5-(tetrahydrofuran-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one;
1,3,3-trimethyl-6-(5-(tetrahydro-2H-pyran-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one;
cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1,3,3-trimethylindolin-2-one;
6-(5-((2-hydroxyethyl)(methyl)amino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one;
(S)-3,3-dimethyl-6-(5-(piperidin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one;
4-((2-(3-(trifluoromethyl)-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one;
3,3-dimethyl-6-(5-((2-oxo-1,2-dihydropyridin-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one;
5-(5-((2-hydroxypyridin-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)isoindolin-1-one;
3,3-dimethyl-6-(5-(methyl(tetrahydro-2H-pyran-4-yl)amino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one;
3,3-dimethyl-6-(5-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one;
N-(1-methyl-1H-indazol-6-yl)-5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
N2-(1-methyl-1H-indazol-6-yl)-N5-(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
trans-6-(5-(4-hydroxy-4-methylcyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one;
cis-6-(5-(4-hydroxy-4-methylcyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one;
cis-4-(2-(4-fluoro-3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
(±)-cis-4-(2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yloxy)tetrahydrofuran-3-ol;
(±)-trans-4-(2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)tetrahydrofuran-3-ol;
(R)—N2-(3-methyl-1H-indazol-6-yl)-N5-(tetrahydrofuran-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
3,3-dimethyl-6-(5-(tetrahydro-2H-pyran-4-yloxy)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one;
3-methyl-1-((2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)azetidin-3-ol;
6-(5-(3-hydroxyazetidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one;
6-(5-(3-hydroxy-3-methylazetidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one;
3,3-dimethyl-6-(5-((3-oxopiperazin-1-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one;
6-(5-(hydroxy(tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one;
cis-5-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-2-(2-methoxyethyl)isoindolin-1-one;
trans-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one;
3,3-dimethyl-6-(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one;
3,3-dimethyl-6-(5-(tetrahydro-2H-pyran-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one;
(1S,3R)-3-((2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)methyl)cyclopentanol;
(1R,3R)-3-((2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)methyl)cyclopentanol;
(1R,3S)-3-((2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)methyl)cyclopentanol;
(1S,3S)-3-((2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)methyl)cyclopentanol;
(S)—N2-(3-methyl-1H-indazol-6-yl)-N5-(tetrahydrofuran-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
4-((2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)pyridin-2(1H)-one;
5-((3,3-difluoropiperidin-1-yl)methyl)-N-(3-methyl-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1-(2-hydroxyethyl)indolin-2-one;
2-((2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methylamino)acetamide;
cis-1-(methoxymethyl)-4-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)cyclohexanol;
4-((2-(1-isopropyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one;
N5-methyl-N2-(3-methyl-1H-indazol-6-yl)-N5-(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
2-(methyl(2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)amino)ethanol;
cis-4-(2-(1-(2-hydroxyethyl)-3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1-methylindolin-2-one;
6-(hydroxy(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)pyrimidin-4(3H)-one;
cis-4-(2-(1-(2-methoxyethyl)-3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
cis-4-(2-(2-(hydroxymethyl)-1H-benzo[d]imidazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
cis-4-(2-(2-(methoxymethyl)-1H-benzo[d]imidazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
cis-4-(2-(1-ethyl-3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
cis-5-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-2-(2-hydroxyethyl)isoindolin-1-one;
N-(3-methyl-1H-indazol-6-yl)-5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
(2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)(tetrahydro-2H-pyran-4-yl)methanol;
trans-4-(2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one;
cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,4-dihydroisoquinolin-1(2H)-one;
cis-4-(2-(4-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
(R)-3-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methylamino)pyrrolidin-2-one;
cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-2-(2-hydroxyethyl)isoindolin-1-one;
(±)-3-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methylamino)pyrrolidin-2-one;
4-((2-(3-amino-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)cyclohexanol;
N2-(3-methyl-1H-indazol-6-yl)-N5-(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
cis-4-(2-(4-fluoro-3-(2-methoxyethoxy)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
4-(1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)ethyl)pyridin-2(1H)-one;
(1S,2S)-2-(2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclopentanol;
N-methyl-2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methylamino)acetamide;
4-(5-((3-hydroxycyclopentyl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide (diastereomer 2);
1-(2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)azetidin-3-ol;
cis-4-(2-(3-amino-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
cis-4-(2-(2,3-dimethyl-2H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
cis-4-(2-(1,3-dimethyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
4-((2-(4-fluoro-3-methylphenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)pyridin-2-ol;
N2-(3-methyl-1H-indazol-6-yl)-N5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
4-((2-(6-(4-hydroxypiperidin-1-yl)pyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one;
(S)-2-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methylamino)propanamide;
cis-3-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol (enantiomer 1);
cis-3-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol (enantiomer 2);
trans-3-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol (enantiomer 1);
trans-3-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol (enantiomer 2);
cis-1-(hydroxymethyl)-4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
4-((2-(4-fluoro-3-methylphenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one;
4-((2-(1H-pyrrolo[2,3-b]pyridin-5-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one;
(±)-5-isopropyl-4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one;
cis-4-(2-(3-(methoxymethyl)-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
4-(5-((3-hydroxycyclopentyl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide (diastereomer 1);
(±)-2-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methylamino)propanamide;
1-(3-methyl-1H-indazol-6-yl)-4((2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one;
4-((2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one;
cis-4-(2-(1-methyl-1H-indazol-5-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
cis-4-(2-(1H-benzo[d][1,2,3]triazol-5-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one;
cis-4-((2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)cyclohexanol;
trans-4-((2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)cyclohexanol;
4-(5-(1H-imidazol-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide;
4-(5-(4-hydroxypiperidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide;
cis-4-(2-(1-isopropyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
N-methyl-4-(5-(2-methyl-1H-benzo[d]imidazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide;
cis-4-(2-(3-ethyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
(1R,2R)-2-(4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)pyridin-2-ylamino)cyclopentanol;
N-methyl-4-(5-(piperidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide;
(±)-trans-3-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
(S)-4-(5-(3-hydroxypyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide;
(R)-4-(5-(3-hydroxypyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide;
N-methyl-4-(5-(pyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide;
1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)imidazolidine-2,4-dione;
cis-5-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)isoindolin-1-one;
N-methyl-4-(5-(2-(piperidin-4-yl)ethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide;
cis-4-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)picolinamide;
cis-4-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)picolinonitrile;
1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperidine-3-carboxamide;
5-methyl-4-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one;
(1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)azetidin-3-yl)methanol;
cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)isoindolin-1-one;
cis-4-(2-(2,6-dimethylpyridin-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
4-(5-((4-aminocyclohexyl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide;
4-(1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)ethyl)piperazin-2-one;
4-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazine-2,6-dione;
cis-N5-(4-methoxycyclohexyl)-N5-methyl-N2-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
cis-4-(methyl(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)amino)cyclohexanol;
N-methyl-4-(5-(pyrrolidin-3-ylmethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide;
5-(5-(2-(hydroxymethyl)-1H-benzo[d]imidazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)pyridin-2-ol;
1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)-1,4-diazepan-5-one;
(1S,2R)-2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
(S)-(1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)pyrrolidin-2-yl)methanol;
(R)-(1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)pyrrolidin-2-yl)methanol;
(1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperidin-3-yl)methanol;
(1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperidin-4-yl)methanol;
(S)-3-methyl-4-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one;
N-methyl-4-(5-(piperidin-4-ylmethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide;
cis-4-(2-(2-(2-hydroxyethoxy)pyridin-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
cis-4-(2-(2-(2-(pyrrolidin-1-yl)ethylamino)pyridin-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
cis-4-(2-(4-fluoro-3,5-dimethylphenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
(6-(2-(6-methoxypyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-1H-benzo[d]imidazol-2-yl)methanol;
3-methyl-4-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one;
6-methyl-4-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one;
cis-4-(5-(4-aminocyclohexyloxy)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide;
N-methyl-4-(5-(piperidin-4-yloxy)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide;
(6-(2-(6-methylpyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-1H-benzo[d]imidazol-2-yl)methanol;
1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)tetrahydropyrimidin-2(1H)-one;
1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)azetidin-3-ol;
(R)-(1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)pyrrolidin-2-yl)methanol;
(S)-(1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)pyrrolidin-2-yl)methanol;
2-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methylamino)acetamide;
trans-4-(5-(4-aminocyclohexyloxy)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide;
4-(5-(3-hydroxybenzyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide;
cis-4-(2-(2-(2-(pyrrolidin-1-yl)ethoxy)pyridin-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
cis-1-(5-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)pyridin-2-yl)piperidin-4-ol;
cis-4-(2-(6-(methylamino)pyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
5-(2-aminoethoxy)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
cis-4-(2-(1H-pyrrolo[2,3-b]pyridin-5-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
(6-(2-(6-(dimethylamino)pyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-1H-benzo[d]imidazol-2-yl)methanol;
(R)-1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperidin-3-ol;
(S)-1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperidin-3-ol;
1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)imidazolidin-4-one;
(R)-5-(pyrrolidin-2-ylmethoxy)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
(S)-5-(pyrrolidin-2-ylmethoxy)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
3-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yloxy)propan-1-ol;
cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)pyridin-2-ol;
4-(5-(2-hydroxy-2-(piperidin-4-yl)ethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide;
5-(pyrrolidin-1-yl)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
5-(morpholinomethyl)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
(R)-1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)piperidin-3-ol;
(S)-1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)piperidin-3-ol;
cis-4-(2-(3,4-difluorophenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
2-(4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)pyridin-2-ylamino)ethanol;
cis-4-(2-(6-morpholinopyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
cis-4-(2-(3,5-dimethylphenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yloxy)ethanol;
cis-3-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide;
4-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)pyridin-2(1H)-one;
cis-2-fluoro-5-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide;
cis-4-(2-(4-fluorophenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
cis-4-(2-(4-fluoro-3-methylphenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
5-(3-aminopropoxy)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
cis-4-(2-(2-fluoropyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
(R)-(1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)pyrrolidin-3-yl)methanol;
(S)-(1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)pyrrolidin-3-yl)methanol;
N-methyl-4-(5-(pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide;
(R)-(1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)pyrrolidin-3-yl)methanol;
(S)-(1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)pyrrolidin-3-yl)methanol;
(R)-2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)propan-1-ol;
(S)-2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)propan-1-ol;
N5-isopropyl-N2-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
cis-4-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)pyridin-2-ol;
(R)-1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)pyrrolidin-3-ol;
(S)-1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)pyrrolidin-3-ol;
(1S,2S)-2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
(R)-1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)pyrrolidin-3-ol;
(S)-1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)pyrrolidin-3-ol;
cis-3-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide;
cis-4-(2-(3-methoxyphenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
cis-4-(2-(2-methoxyphenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
cis-3-fluoro-4-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide;
cis-3-fluoro-4-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzonitrile;
cis-4-(2-(6-methoxypyridin-2-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
cis-4-(2-(p-tolylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
cis-4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yloxy)cyclohexanecarboxamide;
1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)piperidin-4-ol;
(1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)piperidin-4-yl)methanol;
cis-2-fluoro-4-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide;
cis-3-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzonitrile;
cis-4-(2-(pyridin-2-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
cis-4-(2-(m-tolylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
cis-4-(2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
5-(piperidin-4-yloxy)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
cis-4-(2-(4-chlorophenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
cis-4-(2-(3-chlorophenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
cis-4-(2-(3-fluorophenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
(1S,2R)-(2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexyl)methanol;
cis-4-(2-(2-fluorophenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
2-methyl-2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)propan-1-ol;
cis-4-(2-(6-(2-hydroxypropan-2-yl)pyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
4-(5-(cis-4-aminocyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide;
(R)-5-(piperidin-3-yloxy)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
(S)-5-(piperidin-3-yloxy)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
4-(5-(cis-4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzonitrile;
cis-4-(2-(1-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
cis-4-(2-(1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
cis-4-(2-(2-(methylamino)pyridin-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
cis-4-(2-(2-methylpyridin-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
cis-4-(2-(5-methoxypyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
cis-5-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)nicotinamide;
cis-5-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)picolinamide;
cis-5-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)pyridin-2-ol;
5-(pyridin-4-ylmethyl)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
(±)-trans-3-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
(1S,2S)-2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclopentanol;
trans-4-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)methyl)cyclohexanol;
(1S,2R)-2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclopentanol;
(1R,2R)-2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclopentanol;
cis-4-(2-(2-methoxypyridin-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
2-(6-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-1H-benzo[d]imidazol-2-yl)propan-2-ol;
5-(1H-imidazo[4,5-b]pyridin-6-yl)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
cis-5-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)picolinonitrile;
cis-4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)methyl)cyclohexanol;
trans-1-methyl-4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
cis-1-methyl-4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
cis-2-(4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexyl)propan-2-ol;
cis-4-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide;
trans-4-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide;
4-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one;
cis-4-(2-(pyridin-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
cis-4-(2-(5-methylpyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
cis-4-(2-(6-methoxypyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
cis-4-(2-(6-(dimethylamino)pyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
5-(piperazin-1-ylmethyl)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
trans-4-(5-(4-aminocyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide;
5-(piperidin-4-ylmethyl)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperidin-4-ol;
trans-2-(4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexyl)propan-2-ol;
trans-4-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)cyclohexanol;
cis-4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)cyclohexanol;
4-(5-(cyclopentylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide;
5-(2-(methoxymethyl)-1H-benzo[d]imidazol-6-yl)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
1-(6-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-1H-benzo[d]imidazol-2-yl)ethanol;
cis-4-(2-(6-methylpyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
(S)—N2-(2-(2-aminoethoxy)pyridin-4-yl)-N5-(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
trans-4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yloxy)cyclohexanecarboxamide;
(1R,2S)-2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclopentanol;
5-((1-ethylpiperidin-4-yl)methyl)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
6-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-1H-benzo[d]imidazole-2-carboxamide;
(6-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-1H-benzo[d]imidazol-2-yl)methanol;
cis-(4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexyl)methanol;
(S)—N2-(6-morpholinopyridin-3-yl)-N5-(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
(R)-2-phenyl-2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)ethanol;
(S)-2-phenyl-2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)ethanol;
trans-(4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexyl)methanol;
4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)pyridin-2-ol;
4-(2-(4-fluorophenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)picolinamide;
cis-4-(2-(4-fluorophenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yloxy)cyclohexanol;
(1S,3R)-3-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclopentanol;
(1S,3S)-3-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclopentanol;
(1R,3R)-3-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclopentanol;
(1R,3S)-3-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclopentanol;
trans-5-(4-aminocyclohexyloxy)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
cis-5-(4-aminocyclohexyloxy)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
5-(2-((methylamino)methyl)benzo[d]oxazol-6-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
2-(2-(4-fluorophenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-1-(piperidin-4-yl)ethanol;
4-(5-(1H-indazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide;
N5-(azepan-3-yl)-N2-(4-fluorophenyl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
N-phenyl-5-(2-(pyrrolidin-1-ylmethyl)-1H-benzo[d]imidazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
cis-4-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide;
4-((2-(4-fluorophenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperidin-4-ol;
2-(2-(4-fluorophenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-1-phenylethanol;
4-(5-(1H-benzo[d][1,2,3]triazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide;
(S)—N5-(piperidin-3-yl)-N2-(pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
(R)—N5-(piperidin-3-yl)-N2-(pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
5-(4-methylisoxazol-3-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
N-(4-fluorophenyl)-5-(1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
N-(4-fluorophenyl)-5-(2-((methylamino)methyl)-1H-benzo[d]imidazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
N2-phenyl-N5-(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
5-(3-amino-1H-indazol-6-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
5-(2-((methylamino)methyl)-1H-benzo[d]imidazol-6-yl)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
N-methyl-4-(5-(tetrahydrofuran-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide;
3-((2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)benzamide;
2-(4-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)pyridin-2-ylamino)ethanol;
5-(2-(2-aminoethoxy)pyridin-4-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
5-(2-aminopyridin-4-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
5-(2-(dimethylamino)pyridin-4-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
N1-(4-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)pyridin-2-yl)ethane-1,2-diamine;
(R)—N2-(isoindolin-5-yl)-N5-(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
(S)—N2-(isoindolin-5-yl)-N5-(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
(R)—N2-(3-amino-1H-indazol-6-yl)-N5-(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
(S)—N2-(3-amino-1H-indazol-6-yl)-N5-(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
4-((2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)benzamide;
cis-4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
(S)—N2-(1H-benzo[d][1,2,3]triazol-6-yl)-N5-(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
(R)—N2-(1H-benzo[d][1,2,3]triazol-6-yl)-N5-(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
N-methyl-4-(5-(tetrahydro-2H-pyran-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide;
5-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzo[d]isoxazol-3-amine;
(R)-5-(3-amino-2-methylpropyl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
(S)-5-(3-amino-2-methylpropyl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
(R)-2-methyl-3-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)propanamide;
(S)-2-methyl-3-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)propanamide;
(R)—N2-(4-fluorophenyl)-N5-(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
(R)—N2-(1-methyl-1H-indazol-6-yl)-N5-(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
(S)—N2-(1H-indazol-6-yl)-N5-(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
(S)—N2-(4-fluorophenyl)-N5-(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
(S)—N2-(1-methyl-1H-indazol-6-yl)-N5-(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
(R)—N2-(1H-indazol-6-yl)-N5-(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
(R)—N5-(piperidin-3-yl)-N2-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
(S)—N5-(piperidin-3-yl)-N2-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
trans-4-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
cis-4-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
N5-methyl-N2, N5-diphenyl-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
5-(5-methylisoxazol-3-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
(R)—N2-phenyl-N5-(pyrrolidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
(S)—N2-phenyl-N5-(pyrrolidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
(R)-4-(5-(piperidin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide;
N5, N5-dimethyl-N2-phenyl-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
N-phenyl-5-(piperidin-3-ylmethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
(R)-2-methyl-3-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)propan-1-ol;
(S)-2-methyl-3-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)propan-1-ol;
5-(2-(methylamino)-1H-benzo[d]imidazol-5-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
N-phenyl-5-(piperidin-4-ylmethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
(S)-4-(5-(piperidin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide;
N2-phenyl-N5-(pyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
5-(1H-indazol-6-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
5-(2-((dimethylamino)methyl)-1H-benzo[d]imidazol-5-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
5-(2-((methylamino)methyl)-1H-benzo[d]imidazol-5-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
N-phenyl-5-(pyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
7-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)isoquinolin-1-amine;
5-(1-(2-aminoethyl)-1H-benzo[d]imidazol-5-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
(1-benzylpiperidin-4-yl)(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methanol;
trans-4-(5-(4-aminocyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide;
cis-4-(5-(4-aminocyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide;
2-(2-aminoethyl)-5-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)isoindolin-1-one;
2-(2-aminoethyl)-6-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)isoindolin-1-one;
5-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)isoindolin-1-one;
(R)—N2-phenyl-N5-(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
5-(3-aminopropyl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
4-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)isoindolin-1-one;
6-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)isoindolin-1-one;
(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)(pyridin-3-yl)methanol;
(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)(piperidin-4-yl)methanol;
5-phenoxy-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
(S)-2-(phenylamino)-N-(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-5-carboxamide;
5-(4-aminobutyl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
5-benzyl-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
(S)—N2-phenyl-N5-(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
cis-N5-(4-aminocyclohexyl)-N2-phenyl-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
phenyl(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methanone;
5-(cyclohexyloxy)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
5-(3-amino-1H-indazol-5-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
N-phenyl-5-(piperidin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
N-phenyl-5-(1,2,3,6-tetrahydropyridin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
5-(1H-benzo[d]imidazol-6-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
5-(1-(2-aminoethyl)-1H-benzo[d]imidazol-6-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
4-(5-(piperidin-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide;
4-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)pyridin-2-ol;
trans-N5-(4-aminocyclohexyl)-N2-phenyl-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
cis-4-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanecarboxamide;
N-phenyl-5-(2-(piperazin-1-yl)pyridin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
5-(2-methoxypyridin-4-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
5-(1H-indazol-5-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
N2-phenyl-N5-(piperidin-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
N-phenyl-5-(pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
5-cyclohexyl-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
N-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)isobutyramide;
N-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)acetamide;
N-phenyl-5-(pyridin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
N2, N5-diphenyl-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
N5-isopropyl-N2-phenyl-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
N2-(3-methylbenzo[d]isoxazol-6-yl)-N5-(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
1-methyl-5-(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1H-benzo[d]imidazol-2(3H)-one;
4-((2-(3-(methoxymethyl)-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one;
N2-(3-methyl-[1,2,4]triazolo[4,3-a]pyridin-7-yl)-N5-(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
N-(5-methyl-6-morpholinopyridin-3-yl)-5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
6-(5-(difluoro(tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one;
3-methyl-N-(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)benzo[d]isoxazol-6-amine;
3-methyl-N-(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-7-amine;
N2-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-N5-(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
5-((tetrahydro-2H-pyran-4-yl)methyl)-N-(3-(trifluoromethyl)-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
cis-4-(2-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
N5-methyl-N2-(1-methyl-1H-indazol-5-yl)-N5-(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
cis-4-(2-(3-methylbenzo[d]isoxazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
3-methyl-N-(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-amine;
cis-tert-butyl 6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethyl-2-oxoindoline-1-carboxylate;
3,3,4-trimethyl-6-(5((3-oxopiperazin-1-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one;
N2-(5-methyl-6-morpholinopyridin-3-yl)-N5-(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
N-(3,4-dimethyl-1H-indazol-6-yl)-5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
6-(5-(isopropylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one;
N-(1-methyl-1H-indazol-5-yl)-5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
N2-(1-methyl-1H-indazol-5-yl)-N5-(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
N-(3-(methoxymethyl)-1H-indazol-6-yl)-5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
cis-4-(2-(1H-pyrazolo[4,3-b]pyridin-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
cis-4-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1,6-dimethylindolin-2-one;
(S)-2-methyl-3-(2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)propan-1-ol;
cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1,4-dimethylindolin-2-one;
N-(4-(1H-1,2,4-triazol-3-yl)phenyl)-5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
3,3-dimethyl-6-(5-((tetrahydrofuran-3-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one;
6-(5-(2-methoxypyridin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one;
4-(5-(cyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide 3,3-dimethyl-6-(5-((tetrahydrofuran-3-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one;
5-(difluoro(tetrahydro-2H-pyran-4-yl)methyl)-N-(3-methyl-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
5-((1,4-dioxan-2-yl)difluoromethyl)-N-(3-methyl-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
3,3-dimethyl-6-(5-methyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one
N2-(4-(1H-1,2,4-triazol-3-yl)phenyl)-N5-(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine;
6-(5-(dimethylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one cis-4-(2-(4-(1H-1,2,4-triazol-3-yl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
cis-4-(2-(3-methyl-[1,2,4]triazolo[4,3-a]pyridin-7-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol;
1-methyl-5-(5-(tetrahydro-2H-pyran-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1H-benzo[d]imidazol-2(3H)-one;
cis-5-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1-methyl-1H-benzo[d]imidazol-2(3H)-one;
or
3,3-dimethyl-6-(5-morpholino-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one.

469 more elements

A compound or pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the compound is

N-(2-((dimethylamino)methyl)-1H-benzo[d]imidazol-6-yl)-5-(3-fluorophenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
5-(3-fluorophenyl)-N-(1H-indazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
(6-(5-(3-fluorophenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1H-benzo[d]imidazol-2-yl)methanol;
5-(3-fluorophenyl)-N-(1-methyl-1H-benzo[d]imidazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
3′-chloro-5′-(2-(4-(methylcarbamoyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)biphenyl-2-carboxamide;
4-(5-(3-(3-aminopropyl)-5-chlorophenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide;
4-(5-(3-(1H-imidazol-5-yl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide;
4-(5-(3-(3-aminopropyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide;
4-(5-(4-(1H-imidazol-4-yl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide;
3-(2-(2-methyl-1H-benzo[d]imidazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenol;
4-(5-(3-(2-aminoethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide;
4-(5-(3-fluorophenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide;
4-(5-(3-chlorophenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide;
3-(2-(benzo[d]isoxazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenol;
4-(5-(3-hydroxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3-methoxy-N-methylbenzamide;
3-(2-(4-(1H-imidazol-2-yl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenol;
N6-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)quinoline-2,6-diamine;
4-(5-(3-carbamoylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide;
3-(2-(1-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenol;
4-(5-(3-methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide;
4-(5-(2-fluorophenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide;
4-(5-(2-chlorophenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide;
N6-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-N3-(piperidin-4-yl)-1H-indazole-3,6-diamine;
3-(2-(4-(aminomethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenol;
4-(5-(3-hydroxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzoic acid;
6-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)quinolin-2-ol;
3-(2-(1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenol;
3-(2-(1-methyl-1H-benzo[d][1,2,3]triazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenol;
4-(2-(4-(methylcarbamoyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzoic acid;
3-(2-(4-(methylcarbamoyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzoic acid;
N-(2-((dimethylamino)methyl)-1H-benzo[d]imidazol-6-yl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
3-(2-(4-morpholinophenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenol;
4-(5-(3-(aminomethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide;
4-(5-(3-hydroxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-(1-methylpiperidin-4-yl)benzamide;
1-methyl-N6-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-1H-indazole-3,6-diamine;
4-(5-(3-hydroxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide;
N-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-2,3-dihydrobenzo[d]isothiazol-6-amine dione;
N-(5-methoxypyridin-3-yl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
N2-(2-aminoethyl)-N4-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)pyridine-2,4-diamine;
N4-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)pyridine-2,4-diamine;
N-(6-morpholinopyridin-3-yl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
N5-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)benzo[d]isoxazole-3,5-diamine;
N-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)benzo[d]isoxazol-5-amine;
N6-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)benzo[d]isoxazole-3,6-diamine;
2-(2-aminoethyl)-5-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)isoindolin-1-one;
N-(2-methyl-1H-benzo[d]imidazol-5-yl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
N-(1-methyl-1H-benzo[d]imidazol-6-yl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
N-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)benzo[d]isoxazol-6-amine;
N-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-1H-benzo[d][1,2,3]triazol-6-amine;
1-(4-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)phenyl)pyrrolidin-2-one;
4-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)picolinamide;
4-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)picolinonitrile;
N-(isoindolin-5-yl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
N-(1-methyl-1H-indazol-6-yl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
N-(1-methyl-1H-benzo[d]imidazol-5-yl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
N-(4-(1H-1,2,4-triazol-5-yl)phenyl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
N6-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-1H-indazole-3,6-diamine;
5-phenyl-N-(pyridin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
N-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)quinolin-6-amine;
1-(5-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-1-yl)ethanone;
N-(1H-indazol-5-yl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
5-(3-(1H-1,2,4-triazol-5-yl)phenyl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
4-(5-(3-cyanophenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide;
4-(5-(3-hydroxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide;
2-fluoro-5-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide;
3-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzonitrile;
3-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide;
N-(1H-indazol-6-yl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
5-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)isoindolin-1-one;
5-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)pyridine-2-ol;
N-(6-methoxypyridin-3-yl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
5-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)picolinamide;
2-fluoro-4-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide;
5-phenyl-N-(pyrimidin-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
5-phenyl-N-(pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
4-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrile;
4-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-(piperidin-4-yl)benzamide;
N-(3-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenyl)acetamide;
N-(4-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenyl)acetamide;
5-(2-fluorophenyl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
5-(3-fluorophenyl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
5-(4-aminophenyl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
3-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrile;
5-(3-(aminomethyl)phenyl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
4-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzamide;
3-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzamide;
5-(3-aminophenyl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
4-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide;
5-(4-fluorophenyl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
4-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenol;
2-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenol;
3-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenol;
N-(4-morpholinophenyl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
N1, N1-dimethyl-N4-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)benzene-1,4-diamine;
N-(3,4-dimethoxyphenyl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
5-(furan-3-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
5-(3-chlorophenyl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
or
N,5-diphenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine.

96 more elements

Dependencies are inferred from the claim text.

Facts

Application: 12/555,018Filed 8 Sep 2009 · us provisional application
Priority: 8 Sep 2008
Published: US 2010/0093698 A115 Apr 2010
Granted: 30 Oct 2012
Term ends: Not estimatedThe source records don’t support an estimate.

Classification45 codes

C07D 471/04
In which the condensed system contains two hetero rings: ortho-condensed systems
A61P 1/00
Drugs for disorders of the alimentary tract or the digestive system
A61P 1/04
Drugs for disorders of the alimentary tract or the digestive system: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of…
A61P 1/16
Drugs for disorders of the alimentary tract or the digestive system: for liver or gallbladder disorders, e.g. hepatoprotective agents,…