Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
AssigneesTrustees of Dartmouth College, OsteoScreen, Inc., The Regents of the Universtiy of California
InventorsMichael B. Sporn, Karen T. Liby, Tadashi Honda, Gregory Mundy, Ross Garrett, Hari Reddi, Gordon W. Gribble, Takahiro Niikura
Life of this patent
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Abstract
The present invention concerns methods for stimulating the growth and repair of bone and cartilage using synthetic triterpenoids and tricyclic-bis-enones. Examples of suitable triterpenoids include CDDO, CDDO-Me, CDDO-Im, and CDDO-Ethylamide. Examples of tricyclic-bis-enones include TBE-31 and TBE-34.
Claims36
A method for stimulating a bone-forming or osteochondrogenic cell comprising:
- a) providing a bone-producing or osteochondrogenic cell;
- b) contacting said cell with an effective amount of a compound having the structure:
- wherein Y is hydroxy, methoxy, ethyl-amino, or
- a pharmaceutically acceptable salt or tautomer thereof;
- and
- c) culturing the cell.
A method of providing bone tissue to a mammal comprising:
- a) providing a bone-producing cell;
- b) contacting said cell with an effective amount of a compound having the structure:
- wherein Y is hydroxy, methoxy, ethyl-amino, or
- a pharmaceutically acceptable salt or tautomer thereof;
- c) culturing the cell to form bone;
- and
- d) implanting said bone to said subject.
A method for producing bone ex vivo comprising:
- a) providing a bone-producing cell;
- b) contacting said cell with an effective amount of a compound having the structure:
- wherein Y is hydroxy, methoxy, ethyl-amino, or
- a pharmaceutically acceptable salt or tautomer thereof;
- and
- c) culturing the cell to form bone.
A method of repairing bone damage in a patient having a bone defect, bone trauma, osteoarthritis, osteoporosis, or Vitamin D deficiency, comprising administering to said patient an amount of a compound effective to repair bone damage, said compound having the structure:
- wherein Y is hydroxy, methoxy, ethyl-amino, or
- a pharmaceutically acceptable salt or tautomer thereof.
A method for stimulating a cartilage-forming cell comprising:
- a) providing a cartilage-producing or osteochondrogenic cell;
- b) contacting said cell with an effective amount of a compound having the structure:
- or
- a pharmaceutically acceptable salt or tautomer thereof;
- and
- c) culturing the cell.
A method of repairing cartilage damage in a patient having cartilage disease or cartilage trauma comprising administering to said patient an amount of a compound effective to repair cartilage damage, said compound having the structure:
- or a pharmaceutically acceptable salt or tautomer thereof.
Dependencies are inferred from the claim text.