Compositions and their uses directed to acetyl-CoA carboxylases

A method of ameliorating or lessening the severity of a metabolic disorder in an animal, comprising administering to the animal an antisense oligonucleotide consisting of 12 to 50 linked nucleosides, wherein the antisense oligonucleotide is at least 85% complementary to human ACC1, human ACC2, or both human ACC1 and human ACC2, wherein expression of the ACC1, the ACC2, or both the ACC1 and ACC2 is reduced, and wherein administering the antisense oligonucleotide to the animal ameliorates or lessens the severity of the metabolic disorder in the animal.