Self-assembling peptide and gel produced from the same
AssigneeMenicon Co., Ltd.
InventorsHidenori Yokoi, Takatoshi Kinoshita
Life of this patent
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Abstract
A self-assembling peptide containing a polar amino acid residue and a nonpolar amino acid residue, wherein the self-assembling peptide contains an acidic amino acid residue and a basic amino acid residue as the polar amino acid residues, a total sum of charge of the acidic amino acid residue and charge of the basic amino acid residue in a neutral region is the number excluding 0, and the self-assembling peptide is capable of forming a beta (β)-sheet structure in which only the nonpolar amino acid residue is arranged on one face upon self-assembly in an aqueous solution.
Claims8
A self-assembling peptide comprising polar amino acid residues and nonpolar amino acid residues,
- wherein the self-assembling peptide consists of 12 to 32 amino acid residues, comprises one or more acidic amino acid residues and one or more basic amino acid residues as the polar amino acid residues,
- wherein the sum of charge of the acidic amino acid residue(s) and charge of the basic amino acid residue(s), when the self-assembling peptide is in a neutral pH environment, is from −3 to −2 or +2 to +3, wherein all of the amino acids in the self-assembling peptide form a beta (β)-sheet structure in which one face consists of only nonpolar amino acid residues upon self-assembly in a neutral aqueous solution, and wherein the nonpolar amino acid residues are selected from the group consisting of alanine, glycine, leucine, isoleucine, methionine, valine, phenylalanine, and tryptophan.
Dependencies are inferred from the claim text.