Back to results
US 8,299,030 B2Granted
Peptide-based compounds
AssigneeGe Healthcare Limited
InventorsAlan Cuthbertson, Bard Indrevoll, Magne Solbakken, Torgrim Engell, Colin Mill Archer, Harry John Wadsworth
Life of this patent
Estimating the term…
Abstract
The invention relates to new peptide-based compounds for use as diagnostic imaging agents or as therapeutic agents wherein the agents comprise targeting vectors which bind to integrin receptors.
Claims20
A pharmaceutical composition comprising an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof, together with one or more pharmaceutically acceptable adjuvants, excipients or diluents:
- wherein:
- G represents glycine
- D represents aspartic acid
- R1 represents —(CH2)n— or —(CH2)n—C6H4— wherein
- n represents a positive integer 1 to 10
- h represents a positive integer 1 or 2
- X1 represents an amino acid residue wherein said amino acid possesses a functional side-chain such as an acid or amine,
- X2 and X4 represent independently an amino acid residue capable of forming a disulfide bond,
- X3 represents arginine, N-methylarginine or an arginine mimetic,
- X5 represents a hydrophobic amino acid or derivatives thereof, and
- X6 represents a thiol-containing amino acid residue, and
- X7 is absent or represents a biomodifier moiety,
- Z1 comprises a chelating agent and/or a radionuclide reporter moiety and
- W1 is absent or represents a spacer moiety.
11 more elements
Dependencies are inferred from the claim text.