US 8,299,029 B2Granted

Stabilised solid compositions of factor VII polypeptides

AssigneeNovo Nordisk Health Care AG

InventorsMichael Bech Jensen, Birthe Lykkegaard Hansen, Troels Kornfelt

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Abstract

The invention relates to chemically as well as physically stable compositions comprising Factor VII or a Factor VII-related polypeptide such that these compositions can be stored, handled and used at room temperature.

Claims24

Dependent claims

A composition comprising a human Factor VIIa polypeptide and a combination of sucrose and a polyol, said composition having a moisture content of not more than about 3%.

Dependencies are inferred from the claim text.

Facts

Application: 11/526,503Filed 25 Sep 2006 · continuation
Priority: DK 2002 0096321 Jun 2002
Published: US 2007/0207956 A16 Sep 2007
Granted: 30 Oct 2012
Term ends: Not estimatedThe source records don’t support an estimate.

Classification18 codes

A61K 38/4846
Serine endopeptidases: factor VII ; Factor IX ; Factor Xa ; Factor XI ; Factor XII
A61K 9/0019
Galenical forms characterised by the site of application: injectable compositions; Intramuscular, intravenous, arterial, subcutaneous…
A61K 9/19
Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles: lyophilised , i.e.…
A61K 47/02
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents…:…

Family

Application60/394,153Us provisional application · filed 3 Jul 2002
Application10/609,780Parent of this continuation · filed 30 Jun 2003
US 2007/0207956 A1Pre-grant publication · published 6 Sep 2007
US 2004/0248793 A1Published application
US 8,299,029 B2This patent

From the US filing history. Foreign family members aren’t listed.

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