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US 8,299,028 B2Granted
Chimeric peptide antagonist for GPCR135 or GPCR142
AssigneeJanssen Pharmaceutica NV
InventorsChester Kuei, Changlu Liu, Cindy M. Pudiak, Jonathan Edward Shelton, Steven W. Sutton
Life of this patent
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Abstract
The chimeric polypeptide R3(BΔ23-27)R/I5 is described, which is a high-affinity antagonist for GPCR1 35 and GPCR1 42 over LGR7.
Claims3
A chimeric polypeptide comprising a B-chain and an A-chain;
- wherein the B-chain comprises the amino acid sequence RAAPYGVRLCGREFIRAVIFTCR (SEQ ID NO:15) and the A-chain comprises an amino acid sequence selected from the group consisting of the amino acid sequence <EDLQTLCCTDGCSMTDLSALC (SEQ ID NO:19) and the amino acid sequence DVLAGLSSSCCKWGCSKSEISSLC (SEQ ID NO:13), wherein <E represents pyro-Glu.
A chimeric polypeptide consisting essentially of a B-chain crosslinked to an A-chain;
- wherein the B-chain comprises the amino acid sequence RAAPYGVRLCGREFIRAVIFTCR (SEQ ID NO:15) and the A-chain comprises an amino acid sequence selected from the group consisting of the amino acid sequence <EDLQTLCCTDGCSMTDLSALC (SEQ ID NO:19) and the amino acid sequence DVLAGLSSSCCKWGCSKSEISSLC (SEQ ID NO:13);
- wherein <E represents pyro-Glu.
Dependencies are inferred from the claim text.