Neuropeptide-2 receptor (Y-2R) agonists

A neuropeptide-2 receptor agonist of the formula (I):

• Y—R1—R2—X—R3—R4—R5—R6—R7—R8—R9—R10—R11—R12—R13—R14—NH2 (I) (SEQ ID NO:
• 1),
• wherein:
• X is (4-Aminomethyl-biphenyl-3-yl)-acetic acid (Cba), (5-piperazin-1-yl-indole-1-yl)-acetic acid (Cip), 3-(4-oxo-6-piperazin-1-yl-4H-quinazolin-3-yl)-propionic acid (HomPqa), (6-[1,4]diazepan-1-yl-4-oxo-4H-quinazolin-3-yl)-acetic acid (Dqa), (6-Oxo-2-piperazin-1-yl-1,6-dihydropurin-7-yl)-acetic acid (Pdp), (2-Piperazin-1-yl-purin-7-yl)-acetic acid (Ppa), (6-Amino-2-piperazin-1-yl-9H-purin-8-yl)-acetic acid (Appa), ((1R,4S)-6-2-Aza-bicyclo[2.2.1]hept-5-yl-4-oxo-4H-quinazolin)-acetic acid (Bqa) or, (1-Oxo-7-piperazin-1-yl-1H-isoquinolin-2-yl)-acetic acid (Pipa),
• Y is H or an acyl moiety,
• R1 is Ile, Ala, (D)Ile, N-methyl Ile, Aib, 1-1Aic, 2-2 Aic, Ach or Acp,
• R2 is Lys, Ala, (D)Lys, N-methyl lys, Nle or (Lys-Gly),
• R3 is Arg, Ala, (D)Arg, N-methyl Arg, Phe, 3,4,5-Trifluoro Phe or 2,3,4,5,6-Pentafluoro Phe,
• R4 is His, Ala, (D)His, N-methyl His, 4-MeOApc, 3-Pal or 4-Pal,
• R5 is Tyr, Ala, (D)Tyr, N-methyl Tyr, Trp, Tic, Bip, Dip, (1)Nal, (2)Nal, 3,4,5-TrifluoroPhe or 2,3,4,5,6-Pentafluoro Phe,
• R6 is Leu, Ala, (D)Leu or N-methyl Leu,
• R7 is Asn, Ala or (D)Asn,
• R8 is Leu or Trp,
• R9 is Val, Ala, (D)Val or N-methyl Val,
• R10 is Thr, Ala or N-methyl Thr,
• R11 is Arg, (D)Arg or N-methyl Arg,
• R12 is Gln or Ala,
• R13 is Arg, (D)Arg or N-methyl Arg, and
• R14 is Tyr, (D) Tyr or N-methyl Tyr, Phe, (1) Nal, (2) Nal, Cha, C-alpha-methyl Tyr, or Trp,
• or a pharmaceutically acceptable salt thereof.