Proteins with an attached short peptide of acidic amino acids
AssigneesSaint Louis University, Kanazawa University, JCR Pharmaceuticals Co., Ltd.
InventorsShunji Tomatsu, Ken'ichi Miyamoto, Masamichi Yamada, Yasuhiro Tosaka, Mana Yamada
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Abstract
Disclosed are a fusion protein comprising enzyme N-acetylgalactosamine-6-sulfate sulfatase and a short peptide consisting of 4-15 acidic amino acids attached to the enzyme on its N-terminal side, a pharmaceutical composition containing the fusion protein, and a method for treatment of type A Morquio disease using the fusion protein. Compared with the native enzyme protein, the fusion protein exhibits higher transferability to bone tissues and improved, higher stability in the blood.
Claims6
A method for treatment of type A Morquio disease, comprising administering to a human patient therewith a therapeutically effective amount of a fusion protein consisting of SEQ ID NO:
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A method for treatment of type A Morquio disease, comprising administering to a human patient therewith a therapeutically effective amount of a pharmaceutical preparation consisting of SEQ ID NO:
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Dependencies are inferred from the claim text.