Use of tight junction antagonists to treat inflammatory bowl disease
AssigneeAlba Therapeutics Corporation
InventorsBlake Paterson, Amir Tamiz, Niranjan Pandey
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Abstract
The present invention provides materials and methods for the treatment of inflammatory bowel disease (e.g., Crohn's disease and ulcerative colitis). Materials of the invention may include compositions comprising one or more tight junction antagonists and optionally one or more therapeutic agents. Methods of the invention may comprise treating a subject in need thereof with a composition comprising one or more tight junction antagonists and, optionally one or more therapeutic agents.
Claims14
A method for treating Inflammatory Bowel Disease (IBD) in a patient in need thereof, the method comprising:
- administering a composition comprising a peptide having the amino acid sequence GGVLVQPG (SEQ ID NO:15) to the duodenum of the patient, wherein the peptide is being administered in a delayed release composition that is stable in gastric fluid and unstable in intestinal fluid so as to release an effective amount of the peptide in the duodenum of the patient.
A method for treating chronic Inflammatory Bowel Disease (IBD) in a patient in need thereof, the method comprising:
- administering a composition comprising a peptide having the amino acid sequence GGVLVQPG (SEQ ID NO:
- 15) in an effective amount to the patient one or more times per day for a plurality of days, wherein the peptide is being administered in a delayed release composition that is stable in gastric fluid and unstable in intestinal fluid so as to release the peptide in the duodenum and jejunum of the patient.
Dependencies are inferred from the claim text.