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US 8,299,016 B2Granted
ILT3 polypeptides and uses thereof
AssigneeThe Trustees of Columbia University in the City of New York
InventorsNicole Suciu-Foca, George Vlad, Raffaello Cortesini
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Abstract
This invention provides a method for inhibiting the rejection of transplanted islet cells, comprising administering to the subject a polypeptide comprising all or a portion of the extracellular domain of ILT3, wherein the polypeptide is water soluble. This invention further provides a method of treating diabetes, by inhibiting the rejection of transplanted islet cells through the administration of the polypeptide to the subject.
Claims10
A method comprising
- 1. identifying a subject having autoimmune diabetes in need of immune suppression, and
- 2. administering to the subject an immunosuppressive amount of a soluble polypeptide comprising the extracellular domain of human ILT3.
Dependencies are inferred from the claim text.