Vector
AssigneesNational Cerebral and Cardiovascular Center, Bridgestone Corporation
InventorsYasuhide Nakayama, Makoto Nagaishi, Mariko Shiba
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Abstract
The present invention provides a vector which can make nucleic acids to be an aggregate and locate a vector containing a cationic polymer to surround the aggregate so as to protect the nucleic acids from the enzyme. The vector comprises a polymer having branched chain(s). Preferably, 3, 4, or 6 branched chains are bonded to benzene ring. It is preferable that the number of the branched chains is higher. As the branched chain(s), a vinyl-series acrylic polymer is preferable. The vector is synthesized by reacting a dithiocarbamate compound with an acrylamide monomer for the branched chain(s).
Claims7
A nucleic-acid-containing complex comprising a nucleic acid and a vector, wherein the vector is represented by a Formula selected from the group consisting of Formula (I) and Formula (II):
- wherein R1-R6 each represent polymer chains, wherein R1-R6 may each be the same or different,
- wherein R7-R10 each represent polymer chains, wherein R7-R10 may each be the same or different,
- wherein the polymer chains represented by R1-R10 are polymers consisting of dimethylaminopropyl acrylamide monomers, and
- wherein said nucleic-acid-containing complex has a particle size of about 50 to about 400 nm.
Dependencies are inferred from the claim text.