Methods for isolating proteons from plasma samples
AssigneeAuburn University
InventorsVitaly J. Vodyanoy, Alexandre M. Saamoylov, Oleg M. Pustovyy
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Abstract
Compositions and methods for the isolation and manipulation of misfolded, or partially misfolded, proteins present in blood and other biological materials are provided. In one aspect of the invention, the compositions, hereinafter termed “proteons” are misfolded or partially misfolded proteins surrounding a metallic nanocluster, termed “proteon nucleation center” (PNC). Also provided are compositions and methods for the isolation and manipulation of proteon nucleation centers (PNCs) upon which the proteons of the present in blood and other biological materials form.
Claims10
A method for isolating proteons from a plasma sample, the method comprising:
- a) adding to the sample isolated proteon nucleation centers (PNCs), the PNCs each comprising metal nanoclusters having average diameter of about 1-2 nm and containing about 40-300 metal atoms selected from the group consisting of copper, zinc, and iron;
- b) heating the sample to increase proteons in the sample;
- and
- c) isolating the proteons from the sample.
A method for isolating proteons from a plasma sample, the method comprising:
- a) adding to the sample isolated proteon nucleation centers (PNCs), the PNCs each comprising metal nanoclusters having average diameter of about 1-2 nm and containing about 40-300 metal atoms selected from the group consisting of copper, zinc, and iron;
- b) heating the sample to increase proteons in the sample;
- c) repeating steps a) and b);
- and
- d) isolating the proteons from the sample.
Dependencies are inferred from the claim text.