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US 8,298,779 B2Granted
Methods, products and treatments for diabetes
AssigneePresident and Fellows of Harvard College
InventorJose A. Halperin
Life of this patent
Estimating the term…
Abstract
The invention involves assays, diagnostics, kits, and assay components for determining levels of K41-glycated CD59 in subjects. Treatments for subjects based upon levels of K41-glycated CD59 also are provided.
Claims27
A method for diagnosing a diabetic condition in a subject, the method comprising:
- detecting glycated CD59 in a sample obtained from the subject, wherein
- if glycated CD59 is detected in the sample above a cut-off value, the subject is diagnosed with having a diabetic condition;
- or
- if glycated CD59 is not detected in the sample above a cut-off value, the subject is not diagnosed with having a diabetic condition.
1 more element
A method for diagnosing a diabetic condition in a subject not previously known to have a diabetic condition, the method comprising:
- detecting glycated CD59 together with other glycated proteins in urine or obtained from the subject using an antibody, or antigen-binding fragment thereof, that binds to glycated proteins, wherein if glycated CD59 or other glycated proteins are detected in the urine above a cut-off value, the subject is diagnosed with having a diabetic condition, or if glycated CD59 or other glycated proteins are not detected in the urine above a cut-off value, the subject is not diagnosed with having a diabetic condition.
A method for diagnosing a diabetic condition in a subject not previously known to have a diabetic condition, the method comprising:
- detecting glycated CD59 in urine obtained from the subject using an antibody, or antigen-binding fragment thereof, that binds to glycated CD59, wherein if glycated CD59 is detected in the urine above a cut-off value, the subject is diagnosed with having a diabetic condition, or if glycated CD59 is not detected in the urine above a cut-off value, the subject is not diagnosed with having a diabetic condition.
A kit for detecting glycated CD59 in a sample comprising:
- an antibody, or antigen-binding fragment thereof, that binds glycated CD59;
- and
- a detection agent.
Dependencies are inferred from the claim text.