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US 8,298,772 B2Granted
Methods of diagnosing acute cardiac disorders using BNP-SP
AssigneeOtago Innovation Limited
InventorsChristopher Joseph Pemberton, Arthur Mark Richards, Michael Gary Nicholls, Timothy Grant Yandle
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Abstract
The invention provides methods for predicting, diagnosing or monitoring acute cardiac disorders, cardiac transplant rejection, or distinguishing acute cardiac disorders from pulmonary disorders, by measuring BNP signal peptide levels in a sample taken from a subject shortly after onset of, or presentation with the disorder or transplant rejection.
Claims35
A method for predicting, diagnosing or monitoring an acute cardiac disorder in a subject, the method comprising:
- a. determining the level of BNP-SP (17-26) (SEQ ID NO:19) in a biological sample obtained from the subject;
- and
- b. comparing the level of BNP-SP (17-26) (SEQ ID NO:19) in the sample with the level of BNP-SP (17-26) (SEQ ID NO:19) in a control,
- wherein a level of BNP-SP (17-26) (SEQ ID NO:19) in the sample that is higher than the control level is indicative of an acute cardiac disorder.
1 more element
Dependencies are inferred from the claim text.