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US 8,298,765 B2Granted
Multifunctional nucleic acid nano-structures
AssigneeCornell University
InventorsDan Luo, Jong Bum Lee
Life of this patent
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Abstract
Compositions and methods are provided for constructing multi-functional nucleic acid nano-structures. Nano-structures are provided incorporating a built-in modularity, including nucleic acid modules. Modules contain moieties including detectible labels, nanoparticles, reactive moieties and other functional groups. Nano-structures can be used for delivery of target compounds, as well as identification of target nucleic acid molecules.
Claims18
A method for detecting the presence of a target nucleic acid, comprising:
- providing a first monomer and a second monomer to a solution comprising the target nucleic acid, each of the first and second monomers formed from an X-shaped nucleic acid and one or more Y-shaped nucleic acids, wherein the first monomer links to the second monomer with the aid of the target nucleic acid to form a dimer;
- and
- polymerizing the dimer to form a polymer;
- wherein polymerizing the dimer comprises photo-polymerizing the dimer.
1 more element
Dependencies are inferred from the claim text.