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US 8,298,606 B2Granted
Methods and compositions for stabilizing the myocardium
AssigneeThe Regents of the University of California
InventorsKevin E. Healy, Samuel Thomas Wall, Mark Ratcliffe, Julius Guccione
Life of this patent
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Abstract
The present invention provides materials and methods that can serve as a prosthetic and/or, for tissue engineer applications, as a supporting matrix in the stabilization of the myocardium.
Claims14
A method of stabilizing an injured or defective myocardial wall in a patient comprising forming a prosthetic in situ by injecting, at a pre-selected site in the myocardial wall of the patient, a polymer network comprising:
- a cross-linked polymer, said cross-linked polymer being a hydrogel;
- and
- a linear polymer, the polymer chains of which are entangled within said cross-linked polymer and derivatized with a bioactive molecule, wherein said linear polymer is not covalently bonded to said cross-linked polymer and said polymer network has an LCST (lower critical solution temperature) above room temperature and at or below mammalian body temperature.
Dependencies are inferred from the claim text.