Film delivery system for tetrahydrolipstatin
AssigneeMonosol Rx, LLC
InventorsGarry L. Myers, Samuel D. Hilbert, Bill J. Boone
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Abstract
The present invention includes a pharmaceutical-based film system which includes various small-scale forms of pharmaceutically active agents, including tetrahydrolipstatin, in a film base. Such forms include nanoparticles, microparticles, and combinations thereof. Methods of producing such film and providing a dosage of the pharmaceutical in a film are also provided.
Claims46
A method of forming a stabilized solid form of a pharmaceutically active agent in a solid matrix wherein said solid form is present in the form of nanoparticles, microparticles, or combinations thereof, with said method comprising the steps of:
- a. providing a mixture of a pharmaceutically active agent having a melting point less than or equal to about 100° C. and at least one water soluble polymer;
- b. adding at least a portion of said mixture to a solvent, said solvent being heated to a temperature above said melting point of said pharmaceutically active agent whereby said active agent melts and forms a liquid dispersion of the active agent in the mixture;
- and
- c. rapidly evaporating the solvent to form a solid matrix containing a stabilized solid dispersion of said pharmaceutically active agent in said solid matrix, wherein said pharmaceutically active agent is present in the form of nanoparticles, microparticles, or combinations thereof.
A method of forming a stabilized solid form of a pharmaceutically active agent in a solid matrix wherein said solid form is present in the form of nanoparticles, microparticles, or combinations thereof, with said method comprising the steps of:
- a. providing a mixture of a pharmaceutically active agent having a melting point less than or equal to about 100° C. and at least one water soluble polymer;
- b. adding at least a portion of said mixture to a solvent, said solvent being heated to a temperature above said melting point of said pharmaceutically active agent whereby said active agent melts and forms a liquid dispersion of the active agent in the mixture;
- and
- c. rapidly evaporating the solvent to form a solid matrix containing a stabilized solid dispersion of said pharmaceutically active agent in said solid matrix, wherein said pharmaceutically active agent is present in the form of nanoparticles, microparticles, or combinations thereof;
- and
- d. gathering the resulting residue, wherein said resulting residue comprises said pharmaceutically active agent in the form of nanoparticles, microparticles, or combinations thereof.
Dependencies are inferred from the claim text.