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US 8,298,577 B2Granted
Effervescent oral opiate dosage forms and methods of administering opiates
AssigneeCephalon, Inc.
InventorDerek Moe
Life of this patent
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Abstract
Opiate containing dosage forms and methods using same are described. These dosage forms include substantially less opiates by weight than known oral formulations. These dosage forms are intended for oral administration across the oral mucosa.
Claims10
A dosage form comprising:
- about 20 to about 200,000 micrograms of an oxycodone, about 15 to about 60% of an effervescent material, wherein said effervescent material comprises an acid source and a source of a reactive base;
- about 0.5 to about 25% w/w of a pH adjusting substance, wherein said pH adjusting substance is different from the acid source and the reactive base in the effervescent material,
- a filler, wherein said filler is mannitol;
- and
- a starch glycolate,
- wherein said dosage form is configured for the delivery of said oxycodone and salts thereof across the oral mucosa as a consequence of buccal, gingival or sublingual administration.
3 more elements
Dependencies are inferred from the claim text.