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US 8,298,568 B2Granted
Oil-in-water type emulsion with low concentration of cationic agent and positive zeta potential
AssigneeNovagali Pharma SA
InventorsSéverine Bague, Betty Philips, Jean-Sébastien Garrigue, Laura Rabinovich-Guilatt, Gregory Lambert
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Abstract
A well tolerated oil-in-water emulsion useful as a delivery vehicle of hydrophobic ingredients such as pharmaceutical drugs, wherein the emulsion particles have a net positive charge and comprises 0.001 to 0.1% of a cationic agent, 0 to 1% of a non ionic surfactant and 0 to 0.5% of an anionic surfactant.
Claims8
An oil-in-water emulsion, comprising:
- colloid particles having an oily core surrounded by an interfacial film;
- said interfacial film having an overall positive charge and comprising, based on total emulsion weight:
- 1) 0.001 to 0.05% by weight of a cationic agent, said cationic agent being cetalkonium chloride,
- 2) a non ionic surfactant, said nonionic surfactant being present in an amount up to 1% by weight and consisting of tyloxapol and poloxamer, and
- 3) 0% by weight of phospholipids;
- and
- said oil core being not higher than 5% weight.
4 more elements
Dependencies are inferred from the claim text.