Polymer no donor predrug nanofiber coating for medical devices and therapy
AssigneeThe University of Akron
InventorsDarrell Reneker, Daniel J. Smith
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Abstract
The present invention relates to nanofibers that produce therapeutic amounts of nitric oxide after a delay period, which allows time to install or implant the device into a patient. The nitric oxide release is thus localized to the area of the organism where NO dosing is indicated. The delay time is achieved by cospinning the NO-producing fiber with a fiber that tends to sequester the former's NO-producing functional groups. Fibers of the present invention may be incorporated into medical devices such as stents or other implantable medical devices to prevent the formation of adhesions or scarring in the area of the implant.
Claims19
A medical device comprising:
- a polymeric carrier fiber, wherein the carrier fiber is capable of reversibly reacting with nitric oxide;
- a nitric oxide predrug;
- and a second fiber, wherein said second fiber functions to sequester said predrug from reactive species.
Dependencies are inferred from the claim text.