Isolation and purification of P. falciparum merozoite protein-142 vaccine
AssigneeThe United States of America as represented by the Secretary of the Army
InventorsJeffrey A. Lyon, Evelina Angov
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Abstract
In this application is the expression and purification of a recombinant Plasmodium falciparum (3D7) MSP-142. The method of the present invention produces a highly purified protein which retains folding and disulfide bridging of the native molecule. The recombinant MSP-142 is useful as a diagnostic reagent, for use in antibody production, and as a vaccine.
Claims10
A vaccine for protection against infection with the 3D7 strain of P. falciparum comprising merozoite surface protein-142 (MSP-142), said vaccine comprising the amino acid sequence set forth as SEQ ID NO:2 and the amino acid sequence set forth as SEQ ID NO:7.
Dependencies are inferred from the claim text.