Anti-autoimmune antibodies for treatment of pemphigus
AssigneeThe Trustees of the University of Pennsylvania
InventorsAimee S. Payne, John R. Stanley, Donald L. Siegel
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Abstract
This invention relates to compositions and methods for the use of anti-autoimmune reagents that specifically bind to anti-desmoglein antibodies, which are responsible for both pemphigus vulgaris and pemphigus foliaceus. In addition, the invention relates to methods and compositions for inhibiting the expression or function of a variable region of an anti-desmoglein (anti-Dsg) pathogenic autoantibody.
Claims7
A method of inhibiting the binding of an anti-desmoglein autoantibody or fragment thereof to desmoglein, said method comprising contacting the anti-desmoglein autoantibody or fragment thereof with a composition comprising an anti-autoimmune reagent that specifically binds to an anti-desmoglein autoantibody or fragment thereof, wherein the anti-autoimmune reagent is a peptide comprising the amino acid sequence of SEQ ID NO:
- 171.
Dependencies are inferred from the claim text.