Human cytomegalovirus neutralizing antibodies and use thereof
AssigneeInstitute for Research in Biomedicine
InventorsAntonio Lanzavecchia, Annalisa Macagno
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Abstract
The invention relates to neutralizing antibodies, and antibody fragments thereof, having high potency in neutralizing hCMV, wherein said antibodies and antibody fragments are specific for one, or a combination of two or more, hCMV gene UL products. The invention also relates to immortalized B cells that produce, and to epitopes that bind to, such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies, antibody fragments, and epitopes in screening methods as well as in the diagnosis, prevention, and therapy of disease.
Claims14
An isolated antibody, or an antigen binding fragment thereof, which binds an epitope recognized by an antibody having heavy and light chains which respectively comprise amino acid sequences as set forth in SEQ ID NOs. 61 and 62, wherein the antibody or fragment inhibits hCMV infection.
Dependencies are inferred from the claim text.