Anti-IL-7 receptor antibodies
AssigneeRinat Neuroscience Corp.
InventorsChia-Yang Lin, Li-Fen Lee, Wenwu Zhai
Life of this patent
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Abstract
The present invention provides antagonizing antibodies that bind to interleukin-7 receptor (IL-7R). The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acids. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof for the treatment and/or prevention of type 2 diabetes and immunological disorders, including type 1 diabetes, multiple sclerosis, rheumatoid arthritis, graft-versus-host disease, and lupus.
Claims10
An isolated antibody which specifically binds to interleukin-7 receptor alpha (IL-7Rα), wherein the antibody comprises:
- a heavy chain variable region (VH) comprising CDR1, CDR2, and CDR3 of SEQ ID NO:
- 40;
- and
- light chain variable region (VL) comprising CDR1, CDR2, and CDR3 of SEQ ID NO:
- 41.
Dependencies are inferred from the claim text.