Antibodies to IL-1R1
AssigneeMedImmune, LLC
InventorsJamie Iain Campbell, Duncan James Cochrane, Donna Kirsty Finch, Maria Anastasia Teresa Groves, David Christopher Lowe, Simon Charles Cruwys
Life of this patent
Estimating the term…
Abstract
This invention relates to binding members, especially antibody molecules, specific for interleukin 1 receptor 1 (IL-1R1). For example, isolated binding members specific for IL-1R1 which competes with IL-1 and IL-1Ra for binding to IL-1R1 and binds Il-1R1 with a KD of 10 pM or less when measured by Kinexa™. The binding members are useful for, inter alia, treatment of disorders mediated by IL-1R1 including rheumatoid arthritis, asthma and chronic obstructive pulmonary disease (COPD).
Claims7
An isolated antibody specific for IL-1R1 comprising a set of CDRs:
- HCDR1, HCDR2, HCDR3, LCDR1, LCDR2 and LCDR3 wherein HCDR1 has the amino acid sequence of SEQ. ID. NO:
- 63;
- HCDR2 has the amino acid sequence of SEQ. ID. NO:
- 64;
- HCDR3 has the amino acid sequence of SEQ. ID. NO:
- 65;
- LCDR1 has the amino acid sequence of SEQ. ID. NO:
- 68;
- LCDR2 has the amino acid sequence of SEQ. ID. NO:
- 69;
- LCDR3 has the amino acid sequence of SEQ. ID. NO:
- 70.
Dependencies are inferred from the claim text.