Methods for bone regeneration using endothelial progenitor cell preparations
AssigneeHepacore Ltd.
InventorsAvner Yayon, Dina Lewinson, Nimrod Rozen
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Abstract
The present invention relates in general to orthopedics and to a method for promoting repair of large bone defects, in particular non-union or delayed union fractures. Specifically the invention concerns the use of endothelial progenitor cell preparations for bone repair.
Claims16
A method of repairing a bone defect in a subject in need thereof which comprises administering to the subject a therapeutically effective amount of a cell preparation comprising endothelial progenitor cells and a pharmaceutically acceptable carrier, wherein the endothelial progenitor cells are administered in a range of concentrations of 107-1011 cells per ml of the pharmaceutically acceptable carrier.
A method of repairing a bone defect in a subject in need thereof which comprises administering to the subject a therapeutically effective amount of a cell preparation comprising endothelial progenitor cells, a pharmaceutically acceptable carrier and a viscous biopolymer, wherein the endothelial progenitor cells are allogeneic or are recovered from the individual being treated, the bone defect is a delayed or non-union fracture or a bone defect caused by trauma, bone resection or radiotherapy, the subject is a human, and the endothelial progenitor cells are administered at least 10 days after the injury or at least two weeks after the trauma, bone resection or radiotherapy, wherein the endothelial progenitor cells are administered in a range of concentrations of 107-1011 cells per ml of the pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.