Helicobacter system and uses thereof
AssigneeOndek Pty. Ltd.
InventorBarry J. Marshall
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Abstract
Helicobacter based preparations comprising a pharmacologically active molecule of interest are disclosed, as well as methods of preparing and using said preparations. In particular, Helicobacter pylori vectors, vector plasmids and recombinant cells that include a sequence encoding a pharmacologically active molecule of interest useful in therapeutic treatments and/or vaccination against disease are provided. Delivery of the pharamacologically active molecules is provided at the mucosal surface, such as the gastric mucosa or nasal membranes, to provide effective and continuous delivery of a pharmacologically active agent. Vectors and shuttle vector constructs are also provided.
Claims9
A method of expressing a non-Helicobacter pharmacologically active molecule of interest in a mammal, the method comprising:
- (a) providing a composition comprising a Helicobacter cell comprising a nucleic acid comprising:
- (i) at least one non-Helicobacter sequence encoding a non-Helicobacter pharmacologically active molecule of interest linked to a secretory signal peptide;
- and
- (ii) a regulatory sequence capable of controlling expression of the non-Helicobacter sequence in the Helicobacter cell, wherein the Helicobacter cell is not a DapE mutant strain;
- and
- (b) administering to the mammal an effective amount of the composition, wherein the Helicobacter cell chronically colonizes the mucosa of said mammal and the non-Helicobacter sequence encoding a non-Helicobacter pharmacologically active molecule of interest is expressed in the mammal.
Dependencies are inferred from the claim text.