Methods of modulating MUC1 expression to inhibit inflammation
AssigneeKwang Chul Kim
InventorKwang Chul Kim
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Abstract
The present invention relates generally to the field of inflammation. More particularly, the present invention relates to reducing release of pro-inflammatory cytokines induced to MUC1 activity. In one aspect, the present invention provides a method of modulating (inhibiting or promoting) an inflammatory response wherein modulation of the inflammatory response is desired, comprising administering an effective amount of an agent which inhibits or promotes MUC-1 function to an individual.
Claims17
A method of treating, inhibiting or reducing inflammation in an organ or tissue of a host comprising:
- administering to said host an agent comprising an activator of TNF-α receptor whereby said agent is effective to increase MUC1 activity in a cell associated with said organ or tissue, and decrease pro-inflammatory cytokine production or secretion induced by a Toll like receptor wherein said agent is in an amount sufficient to treat, inhibit or reduce inflammation,
- wherein
- the agent is not TNF-α, Pseudomonas aeruginosa, or its purified flagellin;
- the pro-inflammatory cytokines production or secretion induced by a Toll like receptor is decreased after the administration of the agent;
- and
- the administration of the agent results in phosphorylation of at least one amino acid on the cytoplasmic tail of MUC1.
A method of inhibiting release of pro-inflammatory cytokines from cells after stimulation of a Toll-like receptor comprising:
- administering to cells an effective amount of an agent comprising an activator of a TNFα receptor whereby said agent is effective to activate and/or upregulate MUC1 and wherein said agent is not TNFα, Pseudomonas aeruginosa, or its purified flagellin;
- the release of pro-inflammatory cytokines is inhibited after the administration;
- and the administration of the agent results in phosphorylation of at least one amino acid on the cytoplasmic tail of MUC1.
A method of promoting clearance of bacteria from the lung of a host and inhibiting MUC1 activity comprising:
- administering to said host an effective amount of an agent that decreases activation of the MUC1 protein,
- wherein
- the agent is not TNF-α, Pseudomonas aeruginosa, or its purified flagellin;
- the bacteria is cleared from the lung of a host and the activity of MUC1 is inhibited after the administration of the agent;
- and
- the administration of the agent results in inhibition of phosphorylation on the cytoplasmic tail of MUC1.
Dependencies are inferred from the claim text.