Treatment for eye disorder

A method of treating age-related macular degeneration in at least one eye of an individual, said macular degeneration characterized by a thickened Bruch's membrane, comprising:

• administering to said individual an inactivated diffusion-enhancing molecule in an amount sufficient for said molecule to associate with the Bruch's membrane to form a Bruch's membrane/inactive diffusion-enhancing molecule complex, wherein said inactivated diffusion-enhancing molecule is administered in a pharmacologically acceptable composition;
• and
• exposing the complex to an activating source, wherein following said exposing step, diffusion across the Bruch's membrane of said eye improves.

A method for altering an ocular tissue in an individual, comprising the steps of:

• administering to the ocular tissue a pharmacologically acceptable composition comprising an inactive form of a tissue-altering molecule in an amount sufficient to form a Bruch's membrane/inactive tissue-altering molecule complex;
• and
• exposing said complex to an activating source, wherein said activating source activates said inactive tissue-altering molecule into an active form of said tissue-altering molecule, said activation resulting in alteration of at least part of said Bruch's membrane.