Hexatriene-β-carbonyl compound
AssigneesOsaka University, Riken
InventorsKoichi Fukase, Katsunori Tanaka, Yasuyoshi Watanabe, Tsuyoshi Tahara, Koki Hasegawa
Life of this patent
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Abstract
A label with which labeling is easy when labeling a molecule, i.e., a label that has a high reaction rate upon labeling and that produces a high reaction yield, as well as a precursor for the production of the label are provided. This is achieved by a hexatriene-β-carbonyl compound represented by Formula (I), a hexatriene-β-carbonyl compound represented by Formula (II), a hexatriene-β-carbonyl compound represented by Formula (III) and a hexatriene-β-carbonyl compound represented by Formula (IV). (wherein R1, R2, R3, R4, R5, X1, X2 and Z are as defined in the specification)
Claims2
A compound represented by formula (I):
- wherein,
- R1 is a group represented by —CH2OH or —CH2—OR11,
- R2 is a hydrogen atom, a lower alkyl group, a lower alkyl group substituted with one or more substituents, an ar(lower)alkyl group, an ar(lower)alkyl group substituted with one or more substituents, an aryl group, an aryl group substituted with one or more substituents, a heteroaryl group, a heteroaryl group substituted with one or more substituents, or a group represented by a formula:
- -L2-A2-M2,
- R3 is a hydrogen atom, a lower alkyl group, a lower alkyl group substituted with one or more substituents, an ar(lower)alkyl group, an ar(lower)alkyl group substituted with one or more substituents, an aryl group, an aryl group substituted with one or more substituents, a heteroaryl group, a heteroaryl group substituted with one or more substituents, or a group represented by a formula:
- -L1-A1-M1, a formula:
- -L1-N3, or a formula:
- -L1-C≡CH,
- wherein, when R2 is the hydrogen atom, the lower alkyl group, the lower alkyl group substituted with one or more substituents, the ar(lower)alkyl group, the ar(lower)alkyl group substituted with one or more substituents, the aryl group, the aryl group substituted with one or more substituents, the heteroaryl group, or the heteroaryl group substituted with one or more substituents, R3 is the group represented by the formula:
- -L1-A1-M1, the formula:
- -L1-N3, or the formula -L1-C≡CH, and
- when R2 is a group represented by the formula -L2-A2-M2, R3 is the hydrogen atom, the lower alkyl group, the lower alkyl group substituted with one or more substituents, the ar(lower)alkyl group, the ar(lower)alkyl group substituted with one or more substituents, the aryl group, the aryl group substituted with one or more substituents, the heteroaryl group, or the heteroaryl group substituted with one or more substituents, and
- Z is
- a divalent group derived from an aromatic hydrocarbon;
- and
- in the formulae above,
- L1 is a group represented by a formula:
- —(CH2)n—, a formula:
- —(CH2)n—O—(CH2)m—, a formula:
- —(CH2)n—CONH—, or a formula:
- —CONH—(CH2)n—,
- wherein n and m each independently represent an integer of 1 to 20,
- A1 is a group represented by —NH—,
- L2 is a bond or a group represented by —(CH2)n—O—(CH2)m—
- wherein n and m each independently represent an integer of 1 to 20,
- A2 is a group represented by —O—, —CO2—, —S—, or —NH—,
- M1 is a hydrogen atom,
- M2 is a hydrogen atom or a protecting group for a group represented by —OH, —CO2H, —SH or —NH2,
- R11 is a protecting group for a hydroxyl group,
- R12 is a hydrogen atom, a lower alkyl group, a lower alkyl group substituted with one or more substituents, a lower alkoxy group, a lower alkoxy group substituted with one or more substituents, an ar(lower)alkyl group, an ar(lower)alkyl group substituted with one or more substituents, an ar(lower)alkoxy group, an ar(lower)alkoxy group substituted with one or more substituents, an aryl group, an aryl group substituted with one or more substituents, a heteroaryl group or a heteroaryl group substituted with one or more substituents, and
- R13 is a hydrogen atom, a lower alkyl group, a lower alkyl group substituted with one or more substituents, a lower alkoxy group, a lower alkoxy group substituted with one or more substituents, an ar(lower)alkyl group, an ar(lower)alkyl group substituted with one or more substituents, an ar(lower)alkoxy group, an ar(lower)alkoxy group substituted with one or more substituents, an aryl group, an aryl group substituted with one or more substituents, a heteroaryl group or a heteroaryl group substituted with one or more substituents.
Dependencies are inferred from the claim text.