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US 8,298,392 B2Granted
Microfluidic devices and methods of using same
AssigneeUniversity of Louisville Research Foundation, Inc.
InventorsRathissh Dorairaj, Robert S. Keynton, Thomas J. Roussel, Jr., Carolyn M. Klinge, Wasana Sumanasekera, Gamini Sumanasekera
Life of this patent
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Abstract
The presently-disclosed subject matter provides microfluidic devices comprised of two or more carbon nanotube membranes disposed at predetermined intervals within a microchannel. Further provided are methods of using the same for the electrokinetic separation of one or more molecules of interest from a sample.
Claims23
A micro fluidic device, comprising:
- an input reservoir for receiving a sample containing one or more molecules of interest;
- a microchannel in fluid communication with the input reservoir;
- two or more carbon nanotube membranes disposed at predetermined intervals within the microchannel, each carbon nanotube membrane having a width along the longitudinal axis of the microchannel that allows for a substantially uninterrupted voltage gradient to be established upon generation of an electric field;
- and
- a means for generating the electric field through the microchannel such that the electric field induces molecules from the sample in the input reservoir to migrate into the microchannel and up to or through the two or more carbon nanotube membranes, thereby producing electrokinetic separation of molecules from the sample.
2 more elements
A method of electrokinetically separating one or more molecules in a sample, comprising:
- providing a micro fluidic device, including
- an input reservoir for receiving a sample containing one or more molecules of interest,
- a microchannel in fluid communication with the input reservoir, and
- two or more carbon nanotube membranes disposed at predetermined intervals within the microchannel, each carbon nanotube membrane having a width along the longitudinal axis of the microchannel that allows for a substantially uninterrupted voltage gradient to be established upon generation of an electric field;
- placing a sample in the input reservoir;
- and
- generating the electric field through the microchannel, wherein the electric field induces molecules from the sample in the input reservoir to migrate into the microchannel and up to or through the two or more carbon nanotube membranes, thereby producing electrokinetic separation of molecules from the sample.
4 more elements
A micro fluidic device, comprising:
- an input reservoir for receiving a sample containing one or more molecules of interest;
- a plurality of microchannels, wherein each microchannel is in fluid communication with the input reservoir;
- two or more carbon nanotube membranes disposed at predetermined intervals within each microchannel, each carbon nanotube membrane having a width along the longitudinal axis of the microchannel that allows for a substantially uninterrupted voltage gradient to be established upon generation of an electric field;
- and
- a means for generating the electric field through each microchannel such that the electric field induces molecules from the sample in the input reservoir to migrate into each of the microchannels and up to or through the two or more carbon nanotube membranes, thereby producing electrokinetic separation of molecules from the sample.
2 more elements
Dependencies are inferred from the claim text.