Compliant, long-lasting absorbable monofilament sutures
AssigneePoly-Med, Inc.
InventorsShalaby W Shalaby, James M Lindsey, III
Life of this patent
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Abstract
Monofilament sutures are disclosed, which are formed of complaint, segmented, polyaxial, absorbable copolyesters. The sutures are capable of retaining at least 50 percent of their initial breaking strength after 6 weeks following placement in animal or human tissues.
Claims7
A compliant, absorbable monofilament suture having a modulus of less than 400 Kpsi and exhibiting an in vivo breaking strength retention of at least 35 percent at six (6)weeks comprising a crystalline, segmented, polyaxial copolyester comprising a crystalline core made by the polymerization of ε-caprolactone and l-lactide in the presence of an initiator selected from trimethylolpropane and triethanolamine, the crystalline core end-grafted with at least 90 weight percent l-lactide and up to 10 weight percent ε-caprolactone, the copolyester having a melting point below about 50° C.
A compliant, absorbable monofilament suture having a tensile modulus of less than about 400 Kpsi and exhibiting an in vivo breaking strength retention of at least 50 percent at six (6) weeks comprising a crystalline, segmented, polyaxial end-grafted polymer comprising an amorphous non-crystalline polyaxial core made by the polymerization of ε-caprolactone and trimethylene carbonate in the presence of an initiator selected from trimethylolpropane and triethanolamine, the amorphous core end-grafted with at least 90 weight percent l-lactide and up to 10 weight percent of at least one cyclic monomer selected from ε-caprolactone and trimethylene carbonate.
Dependencies are inferred from the claim text.