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US 8,298,176 B2Granted
Flow-induced delivery from a drug mass
AssigneeNeurosystec Corporation
InventorsThomas J. Lobl, Anna Imola Nagy, Jacob E. Pananen, John V. Schloss
Life of this patent
Estimating the term…
Abstract
Drug solutions (or other combinations of vehicle with entrained drug) are prepared by removing drug from one or more masses of a solid form of the drug. The solid form of the drug may be sparingly soluble or insoluble in water. Examples of devices for holding solid drug and facilitating delivery of such drug to targeted regions are also described.
Claims11
A method, comprising:
- implanting a reservoir into a human or other animal, the reservoir containing a mass of a solid form of a drug that is sparingly water-soluble;
- passing vehicle from a source past the solid drug mass so as to entrain drug from the mass;
- and
- delivering the passed vehicle and entrained drug to a target tissue in the human or other animal, and wherein the solid form of the drug is a basic form and the vehicle includes an acid at a concentration that is substantially the same as a predetermined desired therapeutically-effective concentration.
1 more element
A method, comprising:
- implanting a reservoir into a human or other animal, the reservoir containing a mass of a solid form of a drug that is sparingly water-soluble;
- passing vehicle from a source past the solid drug mass so as to entrain drug from the mass;
- and
- delivering the passed vehicle and entrained drug to a target tissue in the human or other animal, and wherein the solid form of the drug is an acidic form and the vehicle includes a base at a concentration that is substantially the same as a predetermined desired therapeutically-effective concentration.
1 more element
A method, comprising:
- implanting a reservoir into a human or other animal, the reservoir containing a mass of a solid form of a drug that is sparingly water-soluble;
- passing vehicle from a source past the solid drug mass so as to entrain drug from the mass;
- and
- delivering the passed vehicle and entrained drug to a target tissue in the human or other animal, wherein the vehicle includes a component having an amphipathic molecule.
1 more element
A method, comprising:
- implanting a reservoir into a human or other animal, the reservoir containing a mass of a solid form of a drug that is sparingly water-soluble;
- passing vehicle from a source past the solid drug mass so as to entrain drug from the mass;
- and
- delivering the passed vehicle and entrained drug to a target tissue in the human or other animal, wherein the vehicle comprises a suspension of nanoparticles having an affinity for the drug.
1 more element
Dependencies are inferred from the claim text.