Method for producing 6-hydroxyethylpenam compound
AssigneeOtsuka Chemical Co., Ltd.
InventorsHideo Tanaka, Manabu Kuroboshi, Syoichi Tateyama, Takae Yamada, Yutaka Kameyama
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Abstract
The present invention provides a method by which a 6-hydroxyethyl penam compound represented by General Formula (2) below can be produced with a high selectivity: wherein R represents a hydrogen atom or a protective group for carboxylic acid and X2 represents a halogen atom; the method including the steps of reacting a Grignard reagent with a halogeno penam compound represented by General Formula (1) below: wherein R and X2 are the same as above, and X1 represents a halogen atom; reacting the generated compound with an amine compound; and further reacting the generated compound with acetaldehyde.
Claims4
A method for producing a penam,
- wherein the penam is a 6-hydroxyethyl penam represented by Formula (2) below:
- wherein R represents a hydrogen atom or a protective group for carboxylic acid, and X2 represents a halogen atom,
- the method comprising the steps of:
- adding a Grignard reagent to a halogeno penam represented by Formula (1) below:
- wherein R and X2 are the same as above, and X1 represents a halogen atom;
- adding an amine to the generated compound;
- and
- further adding acetaldehyde to the generated compound.
Dependencies are inferred from the claim text.