Prognostic panel for urinary bladder cancer
AssigneeUniversity of Southern California
InventorsRichard J. Cote, Anirban P. Mitra
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Abstract
The present invention relates to methods of prognosing urothelial carcinoma. In one embodiment, the present invention provides a method of prognosing urothelial carcinoma by determining expression levels of JUN, MAP2K6, STAT3 and/or ICAM1. In another embodiment, the present invention provides an single prognostic panel made up of eight gene markers. In another embodiment, the present invention provides a single prognostic panel made up of eleven gene markers.
Claims14
A kit for prognostic use, comprising:
- a single prognostic panel consisting essentially of:
- v-jun sarcoma virus 17 oncogene homolog (JUN), mitogen-activated protein kinase kinase 6 (MAP2K6), signal transducer and activator of transcription 3 (STAT3), and intercellular adhesion molecule 1 (ICAM1).
A method of determining a prognosis of cancer characterized by disease recurrence despite possible future treatment with definitive surgery in an individual, comprising:
- determining the presence or absence of a high level of expression in the individual relative to a normal baseline standard for a single prognostic panel consisting essentially of the following markers:
- JUN, MAP2K6, STAT3, and ICAM1;
- and
- prognosing a case of cancer characterized by disease recurrence despite possible future treatment with definitive surgery if the individual demonstrates the presence of a high level of expression relative to a normal baseline standard of at least two of the markers.
A method of treating cancer characterized by disease recurrence despite possible future treatment with definitive surgery in an individual, comprising:
- determining the presence or absence of a high level of expression in the individual relative to a normal baseline standard for a single prognostic panel consisting essentially of the following markers:
- JUN, MAP2K6, STAT3, and ICAM1;
- prognosing a case of cancer characterized by disease recurrence despite possible future treatment with definitive surgery if the individual demonstrates the presence of a high level of expression relative to a normal baseline standard of at least two of the markers;
- and
- treating the cancer with a non-surgical treatment if the individual has a prognosis of a case of cancer characterized by disease recurrence despite possible future treatment with definitive surgery.
A kit for prognostic use, comprising:
- a single prognostic panel consisting essentially of:
- JUN, MAP2K6, STAT3, ICAM1, insulin-like growth factor 1 (IGF1), superoxide dismutase 1(SOD1), B-cell lymphoma 2 (BCL2), bone morphogenetic protein 6 (BMP6), mitogen-activated protein kinase 12 (MAPK12), tumor necrosis factor superfamily member 10 (TNFSF10), cyclin A2 (CCNA2), BCL2-like 1 (BCL2L1), transforming growth factor-beta-induced factor (TGIF), FOS-like antigen 1 (FOSL1) and glutathione S-transferase M3 (GSTM3).
A method of determining a prognosis of cancer characterized by disease recurrence despite possible future treatment with definitive surgery in an individual, comprising:
- determining the presence or absence of a high level of expression in the individual relative to a normal baseline standard for a single prognostic panel consisting essentially of the following markers:
- JUN, MAP2K6, STAT3, ICAM1, IGF1, SOD1, BCL2, BMP6, MAPK12, TNFSF10, CCNA2, BCL2L1, TGIF, FOSL1 and GSTM3;
- and
- prognosing a case of cancer characterized by disease recurrence despite possible future treatment with definitive surgery if the individual demonstrates the presence of a high level of expression relative to a normal baseline standard of one or more of the markers.
A kit for prognostic use, comprising:
- a single prognostic panel consisting essentially of:
- JUN, MAP2K6, STAT3, ICAM1, IGF1, SOD1, BCL2, and BMP6.
A method of determining a prognosis of cancer characterized by disease recurrence despite possible future treatment with definitive surgery in an individual, comprising:
- determining the presence or absence of a high level of expression in the individual relative to a normal baseline standard for a single prognostic panel consisting essentially of:
- JUN, MAP2K6, STAT3, ICAM1, IGF1, SOD1, BCL2, and BMP6;
- and
- prognosing a case of cancer characterized by disease recurrence despite possible future treatment with definitive surgery if the individual demonstrates the presence of a high level of expression relative to a normal baseline standard of one or more of the markers.
A kit for prognostic use, comprising:
- a single prognostic panel consisting essentially of:
- MAPK12, JUN, TNFSF10, CCNA2, TGIF, MAP2K6, BCL2L1, STAT3, ICAM1, FOSL1, and GSTM3.
A method of determining a prognosis of cancer characterized by disease recurrence despite possible future treatment with definitive surgery in an individual, comprising:
- determining the presence or absence of a high level of expression in the individual relative to a normal baseline standard for a single prognostic panel consisting essentially of:
- MAPK12, JUN, TNFSF10, CCNA2, TGIF, MAP2K6, BCL2L1, STAT3, ICAM1, FOSL1, and GSTM3;
- and
- prognosing a case of cancer characterized by disease recurrence despite possible future treatment with definitive surgery if the individual demonstrates the presence of a high level of expression relative to a normal baseline standard of one or more of the markers.
Dependencies are inferred from the claim text.