Ophthalmic and otorhinolaryngological device materials containing a reactive NVP macromer

An intraocular lens comprising a polymeric device material, wherein the polymeric device material has an equilibrium water content of:

• 0.5 to 3 weight percent and is formed by polymerizing a composition comprising
• a) 75 to 97% (w/w) of a monofunctional monomer of formula [1]:
• wherein
• B═O(CH2)n, NH(CH2)n, or NCH3(CH2)n;
• R1═H, CH3, CH2CH3, or CH2OH;
• n=0-12;
• A=C6H5 or O(CH2)mC6H5, where the C6H5 group is optionally substituted with —(CH2)nH, —O(CH2)nH, —CH(CH3)2, —C6H5, —OC6H5, —CH2C6H5, F, Cl, Br, or I;
• and
• m=0-22;
• b) a difunctional cross-linking monomer of formula [2]:
• wherein
• R2, R3 independently═H, CH3, CH2CH3, or CH2OH;
• W, W′ independently═O(CH2)d, NH(CH2)d, NCH3(CH2)d, O(CH2)dC6H4, O(CH2CH2O)dCH2, O(CH2CH2CH2O)dCH2, O(CH2CH2CH2CH2O)dCH2, or nothing;
• J=(CH2)a, O(CH2CH2O)b, O, or nothing, provided that if W and W′=nothing, then J≠nothing;
• d=0-12;
• a=1-12;
• and
• b=1-24;
• and
• c) 1 to 8% (w/w) of a macromer of formula [3]:
• wherein:
• D=OCH2CH2S, SCH2C═O, CH3CH(O)CH2S, SCH2CH(OH)CH2O, S(CH2)11O, S(CH2)10C═O, S(CH2)14C═O, S(CH2)15C═O, SC6H4CH2O, CH3CH(S)C═O, S(CH2CH2CH2)O, CH3CH(S)CH(O)CH3, OCH2CH2C(CH3)2S, SCH2CH2C═O, S(CH2)4O, SC6H4CH2C═O, SC6H4C═O, S(CH2)11C═O, CH3CH(O)CH(S)CH3, SC6H4C═O, S(CH2)6OC6H4CH2O, S(CH2)6O, S(CH2)5C═O, S(CH2)7C═O, or S(CH2)9O;
• E=nothing, O(CH2)nNH, O(CH2)nNHC═O, or HN(CH2)nNH;
• n=2-12;
• R1═H, CH3, CH2CH3, or CH2OH;
• and
• p=10-100.