Methods of treating hypertriglyceridemia
AssigneeAmarin Pharmaceuticals Ireland Limited
InventorsMehar Manku, Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni
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Abstract
In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.
Claims17
A method of lowering apolipoprotein B in a subject having a fasting baseline triglyceride level of 500 mg/dl to about 1500 mg/dl, who does not receive a concurrent lipid altering therapy, comprising administering orally to the subject about 4 g per day of a pharmaceutical composition comprising at least about 96% by weight, ethyl eicosapentaenoate (ethyl-EPA) and substantially no docosahexaenoic acid (DHA) or its esters for a period of at least 12 weeks to effect a reduction in apolipoprotein B of at least 5% without substantially increasing LDL-C compared to a second subject having a fasting baseline triglyceride level of 500 mg/dl to about 1500 mg/dl, who does not receive a concurrent lipid altering therapy, and who has not received the pharmaceutical composition.
A method of lowering apolipoprotein B in a subject having a fasting baseline triglyceride level of 500 mg/dl to about 1500 mg/dl, who does not receive a concurrent lipid altering therapy, comprising administering orally to the subject about 4 g per day of a pharmaceutical composition comprising at least about 96% by weight, ethyl eicosapentaenoate and substantially no docosahexaenoic acid or its esters for a period of at least 12 weeks effective to reduce in a first patient population receiving 4 g per day of said composition, members of which first population have a baseline triglyceride level of about 500 mg/dl to about 1500 mg/dl and who do not receive a concurrent lipid altering therapy, a median apolipoprotein B level by at least 5%, compared to a median apolipoprotein B level, observed in a second patient population, members of which second population have a baseline triglyceride level of 500 mg/dl to about 1500 mg/dl, who do not receive a concurrent lipid altering therapy, and who have not received the pharmaceutical composition.
Dependencies are inferred from the claim text.