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US 8,293,478 B2Granted
Method of using autoinducer-2 as a periodontal disease marker
AssigneeKao Corporation
InventorsHatsumi Souno, Hidetake Fujinaka, Junji Nakamura
Life of this patent
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Abstract
A marker for determining the onset of periodontal disease and a marker for determining the progression stage of periodontal disease, each containing autoinducer-2.
Claims14
A method of determining the presence of periodontal disease, comprising:
- (a) collecting a 0.01 to 100 mg specimen from a subject's oral cavity;
- (b) determining the amount of autoinducer-2 contained in the specimen from (a);
- and
- (c) determining that no periodontal disease or mild periodontal disease is present in the subject if the amount of the autoinducer-2 in the specimen from the subject is from 0 to less than 2 nmol.
1 more element
A method of determining the progression stage of periodontal disease, comprising:
- (a) collecting a 0.01 to 100 mg specimen from a subject's oral cavity;
- (b) determining the amount of autoinducer-2 contained in the specimen from (a);
- and
- (c) determining that periodontal disease is progressing in the subject if the amount of the autoinducer-2 in the specimen from the subject is greater than 2 nmol and less than 3 nmol.
1 more element
Dependencies are inferred from the claim text.