Synergistic attenuation of vesicular stomatitis virus, vectors thereof and immunogenic compositions thereof
AssigneeWyeth
InventorsDavid Kirkwood Clarke, Roger Michael Hendry, Stephen A. Udem, Christopher Lee Parks
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Abstract
The present invention broadly relates to the synergistic attenuation of vesicular stomatitis virus (VSV). More particularly, the invention relates to the identification of combined mutation classes which synergistically attenuate the pathogenicity of VSV vectors in mammals and immunogenic compositions thereof.
Claims17
A genetically modified vesicular stomatitis virus (VSV) comprising at least two different classes of mutations in the same VSV genome, wherein the VSV comprises a truncated G gene mutation and an N gene shuffling mutation, wherein the two mutations synergistically attenuate VSV pathogenicity.
Dependencies are inferred from the claim text.