Vasculature and lymphatic system imaging and ablation associated with a local bypass

A method comprising:

• at least partially diverting fluid flow from and returning fluid to a lumen of one or more blood vessel or lymph vessel of a subject to a local bypass;
• locally providing energy selected to elicit image information associated with the fluid flow;
• selectively orienting one or more sensors to the energy selected to elicit the image information;
• locally capturing the image information with the one or more sensors;
• modulating fluid flow, with one or more bypass insert, to and from the local bypass at least partially based on the captured image information;
• analyzing the image information to at least partially identify one or more targets in real time;
• selecting a target area in the local bypass at least partially based on the one or more identified targets;
• and
• locally providing energy to the target area in real time, the energy having a magnitude selected to at least partially ablate the one or more identified targets.

An untethered device comprising:

• a local bypass configured to function in, or proximal to, one or more blood vessel or lymph vessel of a subject;
• one or more first energy source configured to function in, or proximal to, a lumen of the local bypass and to provide energy configured to elicit one or more image responses associated with the local bypass lumen;
• one or more sensors configured to function in, or proximal to, the local bypass lumen and to capture the one or more image responses, wherein the one or more sensors are configured to orient to the one or more first energy source;
• control circuitry coupled to the one or more sensors, and responsive to at least partially identify one or more targets during an expected transit time of the one or more targets through a detection area in, or proximal to, the local bypass lumen at least partially based on the captured one or more image responses;
• one or more second energy source responsive to the control circuitry, and configured to provide ablation energy to a target area in the local bypass lumen during the expected transit time of the one or more targets through the target area;
• and
• wherein the local bypass includes one or more bypass insert responsive to the control circuitry, and configured to modulate at least part of a circumference of the local bypass at least partially based on the one or more image responses captured by the one or more sensors.