System for analyzing tissue perfusion using concentration of indocyanine green in blood

A method of measuring a rate of tissue perfusion, comprising:

• 1) detecting sequentially a concentration of ICG until the concentration of ICG is decreased to a lowest level by injecting the ICG into a living body, radiating light onto the living body using a light source, and measuring intensities of ICG fluorescence generated in the living body with the passage of time after the injection using a photodetector;
• 2) processing the sequential concentration of ICG in the living body detected in the step 1) into numerical data by converting the intensities of ICG fluorescence into numerical values for respective regions and respective times;
• and
• 3) calculating the rates of perfusion from the numerical values,
• wherein the perfusion rates are calculated using the following equation:
• FI
• isc
• =
• PA
• P
• -
• 1
• ⁢
• /
• ⁢
• τ
• ⁢
• (
• ⅇ
• -
• t
• τ
• -
• ⅇ
• -
• Pt
• )
• ⁢
• ⁢
• or
• ⁢
• -
• In
• ⁢
• ⁢
• τ
• -
• T
• max
• τ
• =
• InP
• -
• PT
• max
• ,
• wherein the FIisc (Fluorescence Intensity ischemia) is an intensity of ICG fluorescence of a measurement target tissue, the P is a rate of tissue perfusion, the A is an intensity of fluorescence obtained from ICG image during the first 1 minute, the τ is t1/2/ln2, the t1/2 is a time at which the intensity of ICG fluorescence is half of a highest value and the Tmax is a time at which the intensity of ICG fluorescence in an ischemic tissue is highest.

A method of measuring a rate of tissue perfusion, comprising:

• 1) detecting sequentially a concentration of ICG until the concentration of ICG is decreased to a lowest level by injecting the ICG into a living body, radiating light onto the living body using a light source, and measuring intensities of fluorescence generated in the living body with the passage of time using a photodetector and obtaining an ICG blood vessel image diagram using the intensities of fluorescence;
• 2) acquiring Tmax by analyzing dynamics of the intensities of ICG fluorescence per respective pixel in the ICG blood vessel image diagram;
• and
• 3) calculating the rates of perfusion rate based on the Tmax,
• wherein the perfusion rates are calculated using the following equation:
• -
• In
• ⁢
• ⁢
• τ
• -
• T
• max
• τ
• =
• In
• ⁢
• ⁢
• P
• -
• PT
• max
• ,
• wherein the P is a perfusion rate, and the τ is t1/2/ln2, the t1/2 is a time at which the intensity of ICG fluorescence is half of a highest value and the Tmax is a time at which the intensity of ICG fluorescence in an ischemic tissue is highest.