Back to results
US 8,283,517 B2Granted
Transgenic mouse models of Aβ overexpression
AssigneeProbiodrug AG
InventorsStephan Schilling, Holger Cynis, Hans-Ulrich Demuth, Wolfgang Jagla, Sigrid Graubner
Life of this patent
Estimating the term…
Abstract
A transgenic non-human animal, in particular a transgenic mouse encoding Aβ peptide proteins, which have been implicated in Aβ peptide-related diseases. Cells and cell lines comprising transgenes encoding for Aβ peptide. Methods and compositions for evaluating agents that affect Aβ peptide, for use in compositions for the treatment of Aβ peptide-related diseases.
Claims29
A transgenic non-human animal whose genome comprises:
- a DNA transgene encoding at least one Aβ peptide consisting of AβN3E-42 (SEQ ID NO:
- 1), AβN3Q-42 (SEQ ID NO:
- 2), AβN3E-40 (SEQ ID NO:
- 3) or AβN3Q-40 (SEQ ID NO:
- 4).
2 more elements
A transgenic mouse comprising:
- a transgenic nucleotide sequence encoding Aβ peptide operably linked to a promoter integrated into the genome of the mouse,
- wherein,
- the transgene encodes a peptide consisting of AβN3E-42 (SEQ ID NO:
- 1), AβN3Q-42 (SEQ ID NO:
- 2), AβN3E-40 (SEQ ID NO:
- 3) or AβN3Q-40 (SEQ ID NO:
- 4);
- and
- the mouse demonstrates a phenotype that can be reversed or ameliorated with an Aβ peptide inhibitor of Aβ peptide effects.
6 more elements
Dependencies are inferred from the claim text.