CXCR2 inhibitors

A compound of formula I:

• wherein:
• X is —S—;
• Y1, Y2, Y3 and Y4
• are —CR8—,
• R8 is hydrogen, F or Cl;
• A is cyclohexyl, piperidyl, phenyl, naphthyl, indanyl, 2,3-dihydro-benzo[1,4]dioxanyl, benzo[1,3]-dioxolyl, furyl, thienyl, pyridyl, oxazolyl, isoxazolyl, thiazolyl, imidazolyl, pyrazolyl, pyrazinyl, pyrimidinyl, pyridazinyl, oxadiazolyl, triazolyl, benzothiophenyl, benzoxazolyl, benzothiazolyl, benzimidazolyl, benzoxadiazolyl, benzotriazolyl, benzo-1,1-dioxid-thiophenyl or quinolyl;
• in which cyclohexyl is unsubstituted or substituted by 1, 2 or 3 methyl radicals;
• in which piperidyl is unsubstituted or substituted by alkyl having 1, 2, 3 or 4 carbon atoms, —C(O)CH3, —C(O)CH2CH3, —C(O)-cyclopropyl, —C(O)CF3, —C(O)OC(CH3)3;
• in which the aryl or heteroaryl radical is unsubstituted or substituted by 1, 2 or 3 radicals selected from the group consisting of F, Cl, Br, CN, NO2, SF5,-N(CH3)2, methoxy, ethoxy, alkyl having 1, 2, 3 or 4 carbon atoms, CF3, OCF3, OCH2CF3, OCHF2, SCH3, SOCH3, SO2CH3, SCF3, phenyl, benzyl, pyrazolyl, pyrrolyl and triazolyl, in which phenyl can be substituted by Cl;
• B is —O—C(R11R12)-;
• R11 is hydrogen;
• R12 is hydrogen or methyl;
• D is C(O)OH;
• R1 and R2
• are, independently of one another, alkyl having 1, 2 or 3 carbon atoms;
• or
• R1 and R2
• form, together with the carbon atom to which they are attached, a 3-, 4-, or 5-membered carbon ring;
• and a pharmaceutically acceptable salt thereof.