Process for preparation of sulfamide derivatives

A process for the preparation of a compound of formula (I)

• wherein
• R1 is selected from the group consisting of alkyl, carbocyclyl, aryl, heteroaryl and heterocycloalkyl;
• wherein the alkyl, carbocyclyl, aryl, heteroaryl and heterocycloalkyl is optionally substituted with one or more substituents independently selected from halogen, alkyl, alkoxy, hydroxy, carboxy, halogenated alkyl, halogenated alkoxy, cyano, nitro, amino, alkylamino, dialkylamino, amido, alkylamido, dialkylamindo, alkoxycarbonyl and aryloxycarbonyl;
• R3 and R4 are each independently selected from the group consisting of alkyl, carbocyclyl, aryl, heteroaryl and heterocycloalkyl;
• wherein the alkyl, carbocyclyl, aryl, heteroaryl and heterocycloalkyl is optionally substituted with one or more substituents independently selected from halogen, alkyl, alkoxy, hydroxy, carboxy, halogenated alkyl, halogenated alkoxy, cyano, nitro, amino, alkylamino, dialkylamino, amido, alkylamido, dialkylamindo, alkoxycarbonyl and aryloxycarbonyl;
• alternatively, R3 and R4 are taken together with the nitrogen atom to which they are bound to form a monocyclic or bicyclic, saturated, partially unsaturated, partially aromatic or aromatic ring structure;
• wherein the ring structure is optionally substituted with one or more substituents independently selected from halogen, alkyl, alkoxy, hydroxy, carboxy, halogenated alkyl, halogenated alkoxy, cyano, nitro, amino, alkylamino, dialkylamino, amido, alkylamido, dialkylamindo, alkoxycarbonyl and aryloxycarbonyl;
• or a pharmaceutically acceptable salt thereof;
• comprising
• reacting a compound of formula (X) with a compound of formula (XI), in the presence of an acid or TMSCI, in a suitable organic solvent, to yield the corresponding compound of formula (XII);
• reducing or hydrogenating the compound of formula (XII), in a suitable organic solvent, to yield the corresponding compound of formula (I).