Process for synthesizing and purifying sucralose
AssigneesZhejiang Hangzhou Xinfu Pharmaceutical Co. Ltd., Shanghai Tongchen Biotech Co., Ltd.
InventorsXinmin Chen, Yanbing Bai, Jianxin Peng
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Abstract
The present invention discloses a process for synthesizing sucralose, which comprises reacting sucrose with acetic anhydride in the solvent of a N-amide compound in the presence of an organic complex alkali metal salt catalyst to produce sucrose-6-acetate, and then chlorinating and deacetylating the sucrose-6-acetate to give sucralose. The present invention also discloses a process for purifying sucralose, which comprises purifying crude sucralose with one or more organic solvents to obtain purified sucralose.
Claims14
A process for synthesizing sucralose, characterized by reacting sucrose as a raw material with acetic anhydride in the solvent of a N-amide compound in the presence of an organic complex alkali metal salt catalyst to produce sucrose-6-acetate, and chlorinating and deacetylating the sucrose-6-acetate to give sucralose;
- wherein the organic complex alkali metal salt catalyst is a mixture of an alkali metal salt and an organic compound, wherein the alkali metal salt is selected from the group consisting of sodium acetate, potassium acetate, sodium carbonate, potassium carbonate, and a combination thereof, and the organic compound is selected from the group consisting of pyridine, diethylamine, triethylamine, DMAP, an aromatic acid, an aromatic sulfonic acid, theophylline, aminophylline, and a mixture thereof.
Dependencies are inferred from the claim text.