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US 8,283,446 B2Granted
T cell receptor mutants
AssigneeImmunocore Limited
InventorsBent Karsten Jakobsen, Nathaniel Ross Liddy
Life of this patent
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Abstract
A T cell receptor (TCR) having the property of binding to EVDPIGHLY HLA-A1 complex and comprising a specified wild type TCR which has specific mutations in the TCR alpha variable domain and/or the TCR beta variable domain to increase affinity. Such TCRs are useful for adoptive therapy.
Claims5
A T cell receptor (TCR) having the property of binding to SEQ ID NO:
- 1-Human Leukocyte Antigen (HLA)-A1 complex and comprising a TCR α variable domain and a TCR β variable domain, wherein:
- the TCR α variable domain has the amino acid sequence from K1 to P114 of SEQ ID NO:
- 2 and the TCR β variable domain has the amino acid sequence from K1 to T112 of SEQ ID NO:
- 3
- except that, in the TCR a variable domain, at least one of the following mutations is present:
- 50I is mutated to 50V;
- 51Q is mutated to 51R;
- 52S is mutated to 52P;
- 53S is mutated to 53Y;
- and/or
- in the TCR beta variable domain, at least one of the following mutations is present:
- 50F is mutated to 50T;
- 51S is mutated to 51D;
- 52E is mutated to 52M;
- 53T is mutated to 53L;
- 54Q is mutated to 54L.
13 more elements
Dependencies are inferred from the claim text.