Extracellular-signal-regulated-kinase (ERK) heteropolyligand polypeptide
AssigneeIntrexon Corporation
InventorThomas David Reed
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Abstract
The invention relates to kinase inhibitor ligands and polyligands. In particular, the invention relates to ligands and polyligands that modulate ERK activity. The ligands and polyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands and polyligands to a cellular localization signal, epitope tag and/or a reporter. The invention also includes polynucleotides encoding the ligands and polyligands.
Claims10
An isolated polypeptide heteropolyligand comprising an amino acid sequence at least 80% identical to the amino acid sequence of SEQ ID NO:1, wherein the heteropolyligand inhibits the kinase activity of extracellular-signal-regulated kinase (ERK).
Dependencies are inferred from the claim text.